Publications associées à Daunorubicine

Computational characterisation of the selectivity and binding mode of mono- and binuclear transition metal based anticancer compounds

Thibaud Edouard Alistair von Erlach

The rising resistance and the severe side effects associated with classical anticancer drugs such as cisplatin or mercaptopurines has triggered the development of novel antitumourous agents based on transition metal (e.g. ruthenium, osmium, and gold) organ ...

EPFL2020

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy

Paul Joseph Dyson, Zhaofu Fei

Combining doxorubicin with thermal therapy in the clinic has led to startling results in the treatment of problematic cancers. Here, we describe a multimo dal multi-walled carbon nanotube material that combines tumor targeting, doxorubicin delivery, and ph ...

Royal Soc Chemistry2017

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin, Edoardo Scherrer

Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect d ...

2015

Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model

Hubert van den Bergh, Georges Wagnières, Laurent Décosterd, Jean Yannis Perentes

Solid tumors are known to have an abnormal vasculature that limits the distribution of chemotherapy. We have recently shown that tumor vessel modulation by low-dose photodynamic therapy (L-PDT) could improve the uptake of macromolecular chemotherapeutic ag ...

Elsevier Science Inc2014

Real-Time Monitoring of Protein Conformational Changes Using a Nano-Mechanical Sensor

Giovanni Dietler, Paolo De Los Rios, Sandor Kasas, Giovanni Longo, Dusan Vobornik, Fabrizio Benedetti, Livan Bladimir Alonso Sarduy

Proteins can switch between different conformations in response to stimuli, such as pH or temperature variations, or to the binding of ligands. Such plasticity and its kinetics can have a crucial functional role, and their characterization has taken center ...

Public Library of Science2014

Photodynamic induced uptake of liposomal doxorubicin to rat lung tumors parallels tumor vascular density

Hubert van den Bergh, Elodie Debefve, Laurent Décosterd

Visudyne®-mediated photodynamic therapy (PDT) at low drug/light conditions has shown to selectively enhance the uptake of liposomal doxorubicin in subpleural localized sarcoma tumors grown on rodent lungs without causing morphological alterations of the lu ...

2012

Insights into Intrastrand Cross-Link Lesions of DNA from QM/MM Molecular Dynamics Simulations

Ursula Röthlisberger, Chandan Patel

DNA damages induced by oxidative intrastrand cross-links have been the subject of intense research during the past decade. Yet, the currently available experimental protocols used to isolate such lesions only allow to get structural information about linke ...

2012

Quantifying supercoiling-induced denaturation bubbles in DNA

Giovanni Dietler

In both eukaryotic and prokaryotic DNA sequences of 30-100 base-pairs rich in AT base-pairs have been identified at which the double helix preferentially unwinds. Such DNA unwinding elements are commonly associated with origins for DNA replication and tran ...

Royal Society of Chemistry2012

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Daunorubicine

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Discovery and Development of Hyperthermia-Enhanced Treatments for Malignant Skin and Uveal Melanomas

Computational characterisation of the selectivity and binding mode of mono- and binuclear transition metal based anticancer compounds

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model

Real-Time Monitoring of Protein Conformational Changes Using a Nano-Mechanical Sensor

Photodynamic induced uptake of liposomal doxorubicin to rat lung tumors parallels tumor vascular density

Insights into Intrastrand Cross-Link Lesions of DNA from QM/MM Molecular Dynamics Simulations

Quantifying supercoiling-induced denaturation bubbles in DNA

Graph Chatbot

Chattez avec Graph Search

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Discovery and Development of Hyperthermia-Enhanced Treatments for Malignant Skin and Uveal Melanomas

Computational characterisation of the selectivity and binding mode of mono- and binuclear transition metal based anticancer compounds

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model

Photodynamic induced uptake of liposomal doxorubicin to rat lung tumors parallels tumor vascular density

Insights into Intrastrand Cross-Link Lesions of DNA from QM/MM Molecular Dynamics Simulations

Real-Time Monitoring of Protein Conformational Changes Using a Nano-Mechanical Sensor

Quantifying supercoiling-induced denaturation bubbles in DNA