Concept
Acide ribonucléique messager
Publications associées (329)
Placeholder factors in ribosome biogenesis: please, pave my way
The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs progressively from the nucleolus to the cytoplasm. In the nucleolus, precursor rRNAs associate with a myriad of trans-acting factors and ...
Shared Science Publishers OG2017Functional analysis of Bicc1 and novel interacting proteins in renal tubule cell metabolism and polycystic kidneys
Genetic disorders known as ciliopathies develop polycystic kidneys, including autosomal
dominant and autosomal recessive polycystic kidney diseases (ADPKD and ARPKD). Several signaling pathways including the cAMP/PKA pathway are implicated in driving cyst ...
EPFL2017Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells
Lysine acetylation is a widespread posttranslational modification affecting many biological pathways. Recent studies indicate that acetylated lysine residues mainly exhibit low acetylation occupancy, but challenges in sample preparation and analysis make i ...
Amer Soc Biochemistry Molecular Biology Inc2017Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gαi1
Ursula Röthlisberger, Siri Camee van Keulen
Adenylyl cyclase (AC) is an important messenger involved in G-protein-coupled-receptor signal transduction pathways, which is a well-known target for drug development. AC is regulated by activated stimulatory (Gαs) and inhibitory (Gαi) G proteins in the cy ...
Public Library of Science2017