Johan AuwerxJohan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland, where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has been using molecular physiology and systems genetics to understand metabolism in health, aging and disease. Much of his work focused on understanding how diet, exercise and hormones control metabolism through changing the expression of genes by altering the activity of transcription factors and their associated cofactors. His work was instrumental for the development of agonists of nuclear receptors - a particular class of transcription factors - into drugs, which now are used to treat high blood lipid levels, fatty liver, and type 2 diabetes. Dr. Auwerx was amongst the first to recognize that transcriptional cofactors, which fine-tune the activity of transcription factors, act as energy sensors/effectors that influence metabolic homeostasis. His research validated these cofactors as novel targets to treat metabolic diseases, and spurred the clinical use of natural compounds, such as resveratrol, as modulators of these cofactor pathways.
Johan Auwerx was elected as a member of EMBO in 2003 and is the recipient of a dozen of international scientific prizes, including the Danone International Nutrition Award, the Oskar Minkowski Prize, and the Morgagni Gold Medal. His work is highly cited by his peers with a h-factor of over 100. He is an editorial board member of several journals, including Cell Metabolism, Molecular Systems Biology, The EMBO Journal, Journal of Cell Biology, Cell, and Science. Dr. Auwerx co-founded a handful of biotech companies, including Carex, PhytoDia, and most recently Mitobridge, and has served on several scientific advisory boards.
Dr. Auwerx received both his MD and PhD in Molecular Endocrinology at the Katholieke Universiteit in Leuven, Belgium. He was a post-doctoral research fellow in the Departments of Medicine and Genetics of the University of Washington in Seattle.
John McKinneyProfessor John McKinney received his Ph.D. from The Rockefeller University (New York, NY) in 1994 for studies on cell cycle regulation in
Saccharomyces cerevisiae
in the laboratory of Fred Cross. From 1995 to 1998, he was a postdoctoral fellow in the laboratory of William Jacobs at the Albert Einstein College of Medicine (Bronx, NY), where he studied mechanisms of persistence in
Mycobacterium tuberculosis
. In 1999, he returned to Rockefeller University to establish his own laboratory as an Assistant (1999-2004) and then Associate (2004-2007) Professor. In July 2007, the lab relocated to the Global Health Institute in the School of Life Sciences at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, where McKinney is Professor and Head of the Laboratory of Microbiology and Microsystems (LMIC). Our research focuses on understanding the mechanistic basis of bacterial persistence in the context of host immunity and antimicrobial therapy, using
M. tuberculosis
as a "model" system.
Stewart ColeProfessor Stewart Cole is an international authority in bacterial molecular-genetics and genomics. He has made outstanding contributions in several fields including: bacterial anaerobic electron transport; genome analysis of retroviruses and papillomaviruses; antibiotic resistance mechanisms; and the molecular microbiology of toxigenic clostridia. His studies on isoniazid and multidrug resistance in Mycobacterium tuberculosis, together with his pioneering work on the pathogenicity, evolution and genomics of the tubercle and leprosy bacilli, have made him an undisputed leader in the field of mycobacterial research. The findings of his research are of direct relevance to public health and disease-control in both the developing world and the industrialised nations. He has published over 250 scientific papers and review articles, and holds many patents.
Didier TronoAprès des études de médecine à l’Université de Genève et une formation clinique en pathologie, médecine interne et maladies infectieuses à Genève et au Massachusetts General Hospital de Boston, Didier Trono s’engage dans une carrière scientifique au Whitehead Institute du MIT. En 1990, il est recruté par le Salk Institute de San Diego pour lancer un centre de recherche sur le SIDA. Il rentre en Europe sept ans plus tard, avant de prendre en 2004 les rênes de la toute nouvelle faculté des Sciences de la Vie de l’EPFL, dont il orchestre le développement et qu’il dirige jusqu’en 2012. Il participe aujourd’hui activement à la coordination des efforts de la Suisse en vue de l’intégration des nouvelles technologies dans le domaine de la médecine de précision et de la santé personnalisée.
Heinrich HofmannOriginaire de Mellingen (AG), Heinrich Hofmann est né en 1953. Après des études d'ingénieur en soudures (Ing. grad.) à Duisburg (D), et d'ingénieur en science des matériaux à la Technische Hochschule de Berlin, il obtient le titre de docteur ingénieur en 1983 pour une thèse dans le domaine des matériaux.De 1983 à 1985, il travaille comme assistant scientifique au Laboratoire de Technologie des Poudres de l'Institut Max Planck pour la science des matériaux à Stuttgart. En 1985 il entre au Centre de Recherche et Développement d'Alusuisse-Lonza à Neuhausen-am-Rheinfall, en tant qu'ingénieur consacré à la recherche dans l'étude et le développement des procédés de synthèse des poudres céramiques.En 1993 il entre à l'EPFL en tant que professeur extraordinaire et directeur du Laboratoire de technologie des poudres du Départmeent des matériaux. Son enseignement porte sur les céramiques I (procédés) et les phénomènes de transfert. Son domaine de recherche couvre la synthèse des poudres minérales, leur caractérisation et la modification des surfaces, ainsi que la mise en forme et le frittage. Ses recherches incluent aussi les matériaux nanostructurés (composites semi-conducteurs et polymères) et la métallurgie des poudres. Hofmann Heinrich, Prof. Dr.-Ing. got his PhD in Material Science with a thesis prepared at the Powder Metallurgy Laboratory at the Max Planck Institute in Stuttgart. In 1985 he joins the R&D center of Alusuisse-Lonza Services AG, at Neuhausen-am-Rheinfall. In 1993 he joins the Swiss Federal Institute of Technology as Professor and Director of the Powder Technology Laboratory at the Department of Materials science and engineering. His research area includes the synthesis of nanostructured materials based on nanoparticles and the modification of surfaces with nanoparticles using colloidal methods. The fields of application of such materials are medical and biological, (drug delivery, hyperthermia, cell separation, biosensors), electronics and sensors.
