Concept
Peptide antimicrobien
Publications associées (201)
Peptide-based virucidal drugs
Before the COVID-19 pandemic, viruses were not a major priority for the scientific community. Today, many events have changed the world and the importance of studying viruses, vaccines, and antiviral drugs is fully appreciated. The development of effective ...
EPFL2024Aptamer-Functionalized Interface Nanopores Enable Amino Acid-Specific Peptide Detection
Nako Nakatsuka, Xinyu Zhang, Haiying Hu
Single-molecule proteomics based on nanopore technology has made significant advances in recent years. However, to achieve nanopore sensing with single amino acid resolution, several bottlenecks must be tackled: controlling nanopore sizes with nanoscale pr ...
2024Gallocin A, an Atypical Two-Peptide Bacteriocin with Intramolecular Disulfide Bonds Required for Activity
Streptococcus gallolyticus subsp. gallolyticus (SGG) is an opportunistic gut pathogen associated with colorectal cancer. We previously showed that colonization of the murine colon by SGG in tumoral conditions was strongly enhanced by the production of gall ...
AMER SOC MICROBIOLOGY2023Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization
Jérôme Waser, Aleksandra Radenovic, Beat Fierz, Xingyu Liu, Nathan Cyprien Arsène Ronceray, Wei Cai
Rapid and efficient cyclization methods that form structurally novel peptidic macrocycles are of high importance for medicinal chemistry. Herein, we report the first gold(I)-catalyzed macrocyclization of peptide-EBXs (ethynylbenziodoxolones) via C2-Trp C–H ...
2023Functional characterization of Drosophila melanogaster immune effectors
Drosophila melanogaster, commonly known as the "fruit fly", is a genetically tractable model organism widely used to study biological processes, notably the innate immune system. The advent of novel genome editing technologies, such as the CRISPR-Cas9 syst ...
EPFL2023The tip protein PAAR is required for the function of the type VI secretion system
Bacteria are constantly competing to colonize crowded ecological niches, such as the human gut. The type VI secretion system (T6SS) is a critical bacterial weapon in this warfare. It resembles a crossbow with a poisoned arrow allowing bacteria to inject to ...
Washington2023Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection
Bruno Lemaitre, Mark Austin Hanson, Alexia Laurie Carboni
Cecropins are small helical secreted peptides with antimicrobial activity that are widely distributed among insects. Genes encoding Cecropins are strongly induced upon infection, pointing to their role in host defense. In Drosophila, four cecropin genes cl ...
OXFORD UNIV PRESS INC2022