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Tige-boucle
Publications associées (31)
Towards improving full-length ribosome density prediction by bridging sequence and graph-based representations
Pierre Vandergheynst, Felix Naef, Cédric Gobet, Francesco Craighero, Mohan Vamsi Nallapareddy
Translation elongation plays an important role in regulating protein concentrations in the cell, and dysregulation of this process has been linked to several human diseases. In this study, we use data from ribo-seq experiments to model ribosome dwell times ...
2024Electronic and structural dynamics in DNA single strands
The absorption, conversion and transport of electronic energy in molecular aggregates is at the heart of many important natural and artificial photochemical systems, including organic solar cell materials, photosynthetic light-harvesting complexes and DNA ...
EPFL2021Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each
Lukas Kühn, Giovanna Ambrosini, Barbara Grisoni-Neupert, Philipp Bucher, Ramona Pauchard-Batschulat, Otto Hagenbüchle
Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in mouse N ...
PUBLIC LIBRARY SCIENCE2018What shapes eukaryotic transcriptional bursting?
Felix Naef, Damien Lionel Nicolas, Nicholas Edward Phillips
Isogenic cells in a common environment present a large degree of heterogeneity in gene expression. Part of this variability is attributed to transcriptional bursting: the stochastic activation and inactivation of promoters that leads to the discontinuous p ...
Royal Society of Chemistry2017On the Relationship Between Protein-DNA Interactions and Circadian Gene Expression in Mouse Liver
Virtually every cell in our body tracks daily time using an endogenous mechanism called the circadian clock, which has a period of about 24 hours. This timing system offers a selective advantage by enabling organisms to anticipate periodic changes in envir ...
EPFL2011