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Publications associées (93)
Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics
Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...
EPFL2024Cross-anatomical single-cell definition and characterization of human adipose progenitor niche
Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...
EPFL2023Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis
Freddy Radtke, Ute Koch, Jialin Zhang, Soufiane Boumahdi
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...
ELSEVIER2023New approaches to uncover the minimally functional hematopoietic niche using the adipocytic differentiation axis: pharmacological modulation and adrenal niche induction
Hematopoietic Stem and Progenitor Cells (HSPCs) reside in their niche, a structure that regulates the balance of cellular quiescence, self-renewal and commitment towards differentiated cells. This highly plastic niche is formed by several cellular players, ...
EPFL2022Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging
Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...
EPFL2022Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner
Bart Deplancke, Julie Marie Russeil, Horia Hashimi, Daniel Alpern, Maria Litovchenko, Pernille Yde Rainer, Magda Zachara, Radiana Ferrero
Adipose stem and precursor cells (ASPCs) give rise to adipocytes and determine the composition and plasticity of adipose tissue. Recently, several studies have demonstrated that ASPCs partition into at least three distinct cell subpopulations, including th ...
WILEY2022Dissecting centriole fate in C. elegans development
The presence of centrioles is critical for fundamental cell and developmental processes, including polarity, migration and division. Although centrioles are present in most proliferating cells, they are thought to vanish after cell cycle exit in some diffe ...
EPFL2022Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis
Asymmetric divisions that yield daughter cells of different sizes are frequent during early embryogenesis, but the importance of such a physical difference for successful development remains poorly understood. Here, we investigated this question using the ...
ELIFE SCIENCES PUBLICATIONS LTD2021PEG/HA Hybrid Hydrogels for Biologically and Mechanically Tailorable Bone Marrow Organoids
Nicolas Antoine Vincent Broguiere, Martin Ehrbar, Queralt Vallmajó Martín
Bone marrow (BM) organoids provide powerful tools to study the vital interplay between the BM microenvironment and resident cells. Current biomaterials, however, are limited in terms of versatility for independently studying the biochemical and biophysical ...
WILEY-V C H VERLAG GMBH2020Polarised three-dimensional cellular aggregates
Matthias Lütolf, Giuliana Rossi
Polarised three-dimensional cellular aggregates (or gastruloids) generated in vitro from one or more pluripotent stem cells are provided. Methods for obtaining polarised three-dimensional cellular aggregates and cells (e.g. progenitor cells and derivatives ...
2020