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Publications associées (10)

Intestinal helminths modulate the gut microbiome

Intestinal parasitic worms (commonly named intestinal helminths) affect close to one quarter of the world population and cause major losses for the livestock industry. These parasites establish chronic infections by modulation the immunity of their host. T ...

EPFL2018

Heterogeneity in schistosomiasis transmission dynamics

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Francisco Javier Perez Saez, Marino Gatto

Simple models of disease propagation often disregard the effects of transmission heterogeneity on the ecological and epidemiological dynamics associated with host-parasite interactions. However, for some diseases like schistosomiasis, a widespread parasiti ...

Academic Press Ltd- Elsevier Science Ltd2017

An ecological and digital epidemiology analysis on the role of human behavior on the 2014 Chikungunya outbreak in Martinique

Marcel Salathé

Understanding the spatio-temporal dynamics of endemic infections is of critical importance for a deeper understanding of pathogen transmission, and for the design of more efficient public health strategies. However, very few studies in this domain have foc ...

2017

Computational Immunohistochemistry: Recipes for Standardization of Immunostaining

Nuri Murat Arar, Maria Gabrani, Aditya Kashyap, Pushpak Pati, Anna Fomitcheva Khartchenko

Cancer diagnosis and personalized cancer treatment are heavily based on the visual assessment of immunohistochemically-stained tissue specimens. The precision of this assessment depends critically on the quality of immunostaining, which is governed by a nu ...

2017

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

Kristina Schoonjans, Alessia Perino

Bile acids and epithelial-derived human beta-defensins (H beta Ds) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic H beta D expression and aimed to t ...

Federation of American Society of Experimental Biology2017

Modeling Key Drivers of Cholera Transmission Dynamics Provides New Perspectives for Parasitology

Andrea Rinaldo, Melanie Blokesch, Enrico Bertuzzo, Lorenzo Mari, Marino Gatto

Hydroclimatological and anthropogenic factors are key drivers of waterborne disease transmission. Information on human settlements and host mobility on waterways along which pathogens and hosts disperse, and relevant hydroclimatological processes, can be a ...

Elsevier2017

Functional intestinal bile acid 7-alpha-dehydroxylation by Clostridium scindens associated with protection from C. difficile infection in a gnotobiotic mouse model

Rizlan Bernier-Latmani, Laure Menin, Lyne Desharnais

Bile acids, important mediators of lipid absorption, also act as hormone-like regulators and as antimicrobial molecules. In all these functions their potency is modulated by a variety of chemical modifications catalyzed by bacteria of the healthy gut micro ...

Frontiers Media Sa2016

Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens

Bruno Lemaitre, Sveta Chakrabarti, Sylvain Kolly

The animal gut plays a central role in tackling two common ecological challenges, nutrient shortage and food-borne parasites, the former by efficient digestion and nutrient absorption, the latter by acting as an immune organ and a barrier. It remains unkno ...

Wiley-Blackwell2015

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

Bruno Lemaitre, Onya Opota, Olivier Binggeli, Takayuki Kuraishi

The peritrophic matrix (PM) forms a layer composed of chitin and glycoproteins that lines the insect intestinal lumen. This physical barrier plays a role analogous to that of mucous secretions of the vertebrate digestive tract and is thought to protect the ...

National Academy of Sciences2011

Impact sanitaire de l'utilisation d'eaux polluées en agriculture urbaine. Cas du maraîchage à Ouagadougou (Burkina Faso)

Gueladio Cissé

In Ouagadougou and in many similar Sahelian cities, urban agriculture uses very often polluted water for irrigation of vegetables, including those that are likely to be eaten uncooked. As the pathogenic germs can survive long enough in water, soil and plan ...

EPFL1997

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