Système de Bethesda

The Bethesda system (TBS), officially called The Bethesda System for Reporting Cervical Cytology, is a system for reporting cervical or vaginal cytologic diagnoses, used for reporting Pap smear results. It was introduced in 1988 and revised in 1991, 2001, and 2014. The name comes from the location (Bethesda, Maryland) of the conference, sponsored by the National Institutes of Health, that established the system. Since 2010, there is also a Bethesda system used for cytopathology of thyroid nodules, which is called The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC or BSRTC). Like TBS, it was the result of a conference sponsored by the NIH and is published in book editions (currently by Springer). Mentions of "the Bethesda system" without further specification usually refer to the cervical system, unless the thyroid context of a discussion is implicit. Abnormal results include: Atypical squamous cells Atypical squamous cells of undetermined significance (ASC-US) Atypical squamous cells – cannot exclude HSIL (ASC-H) Low-grade squamous intraepithelial lesion (LGSIL or LSIL) High grade squamous intraepithelial lesion (HGSIL or HSIL) Squamous cell carcinoma Atypical Glandular Cells not otherwise specified (AGC-NOS) Atypical Glandular Cells, suspicious for AIS or cancer (AGC-neoplastic) Adenocarcinoma in situ (AIS) The results are calculated differently following a Pap smear of the cervix. A low-grade squamous intraepithelial lesion (LSIL or LGSIL) indicates possible cervical dysplasia. LSIL usually indicates mild dysplasia (CIN 1), more than likely caused by a human papillomavirus infection. It is usually diagnosed following a Pap smear. CIN 1 is the most common and most benign form of cervical intraepithelial neoplasia and usually resolves spontaneously within two years. Because of this, LSIL results can be managed with a simple "watch and wait" philosophy. However, because there is a 12–16% chance of progression to more severe dysplasia, the physician may want to follow the results more aggressively by performing a colposcopy with biopsy.

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Néoplasie cervicale intra-épithéliale

La néoplasie cervicale intra-épithéliale (NCI), également connue sous le nom de dysplasie cervicale, est la croissance anormale de cellules à la surface du col de l'utérus qui pourrait potentiellement conduire au cancer du col de l'utérus. Plus spécifiquement, NCI fait référence à la transformation potentiellement précancéreuse des cellules du col de l'utérus. La néoplasie cervicale intra-épithéliale se produit le plus souvent à la jonction pavimento-cylindrique du col de l'utérus, une zone de transition entre l'épithélium pavimenteux du vagin et l'épithélium cylindrique de l'endocol.

Pap test

The Papanicolaou test (abbreviated as Pap test, also known as Pap smear (AE), cervical smear (BE), cervical screening (BE), or smear test (BE)) is a method of cervical screening used to detect potentially precancerous and cancerous processes in the cervix (opening of the uterus or womb) or colon (in both men and women). Abnormal findings are often followed up by more sensitive diagnostic procedures and, if warranted, interventions that aim to prevent progression to cervical cancer.

Papillomavirus humain

La dénomination « 'papillomavirus humain » (PVH) ou virus du papillome humain' (VPH, en anglais human papillomavirus, HPV) s'applique à différents virus à ADN de la famille des Papillomaviridae susceptibles d'infecter l'humain. On en connaît environ différents ; certains se transmettent par contact cutané et infectent la peau, d'autres potentiellement plus dangereux sont sexuellement transmissibles.

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Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia

Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system ...

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Arginine-Based Biodegradable Ether–Ester Polymers with Low Cytotoxicity as Potential Gene Carriers

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The success of gene therapy depends on safe and effective gene carriers. Despite being widely used, synthetic vectors based on poly(ethylenimine) (PEI), poly(l-lysine) (PLL), or poly(l-arginine) (poly-Arg) are not yet fully satisfactory. Thus, both improve ...

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