Concept

Artificial skin

Publications associées (28)

Molecular and mechanical regulators of lymphatic biology

Lymphatic vessels exist in nearly all tissues, yet, despite their omnipresence, there remains a large knowledge gap between the described fundamental roles of lymphatic capillaries and our understanding of their functional biology, adaptive ability, and pa ...

EPFL2008

Two-dimensional microimpedance imaging for cell culture monitoring

Olof Pontus Linderholm

This thesis presents the fabrication and design of an impedance imaging sensor, and its application to monitoring in-vitro skin culture. Three-dimensional tissue cultures are becoming increasingly important in biological and medical research. There is, how ...

EPFL2006

Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes

Jean-Jacques Meister, Boris Hinz

Myofibroblasts are specialized fibroblasts that contribute to wound healing by producing extracellular matrix and by contracting the granulation tissue. They appear in a phase of wound healing when the dermis strongly interacts with activated epidermal ker ...

Schattauer2004

Myofibroblast development is characterized by specific cell-cell adherens junctions

Jean-Jacques Meister, Boris Hinz, Philippe Pittet, Josiane Angèle Charlotte Smith-Clerc

Myofibroblasts of wound granulation tissue, in contrast to dermal fibroblasts, join stress fibers at sites of cadherin-type intercellular adherens junctions (AJs). However, the function of myofibroblast AJs, their molecular composition, and the mechanisms ...

American Society for Cell Biology2004

Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts

Boris Hinz

Cultured myofibroblasts are characterized by stress fibers, containing alpha-smooth muscle actin (alpha-SMA) and by supermature focal adhesions (FAs), which are larger than FAs of alpha-SMA-negative fibroblasts. We have investigated the role of alpha-SMA f ...

American Society for Cell Biology2003

Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth

Matthias Lütolf, Jeffrey Alan Hubbell, Martin Ehrbar

Local, controlled induction of angiogenesis remains a challenge that limits tissue engineering approaches to replace or restore diseased tissues. We present a new class of bioactive synthetic hydrogel matrices based on poly(ethylene glycol) (PEG) and synth ...

2003

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice

Denis Duboule, Jozsef Zakany, Walter Wahli

We show here that the alpha, beta, and gamma isotypes of peroxisome proliferator-activated receptor (PPAR) are expressed in the mouse epidermis during fetal development and that they disappear progressively from the interfollicular epithelium after birth. ...

2001

Mechanical stress is communicated between different cell types to elicit matrix remodeling

Melody Swartz

Tissue remodeling often reflects alterations in local mechanical conditions and manifests as an integrated response among the different cell types that share, and thus cooperatively manage, an extracellular matrix. Here we examine how two different cell ty ...

2001

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