Concept

Somatic (biology)

Publications associées (20)

Epigenetic memory in induced pluripotent stem cells

Olaia Maria Naveiras Torres-Quiroga, Kyungjin Kim, Ji Hyun Kim

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, these two reprogramming methods ...

2010

In Drosophila melanogaster the COM Locus Directs the Somatic Silencing of Two Retrotransposons through both Piwi-Dependent and -Independent Pathways

Background. In the Drosophila germ line, repeat-associated small interfering RNAs (rasiRNAs) ensure genomic stability by silencing endogenous transposable elements. This RNA silencing involves small RNAs of 26-30 nucleotides that are mainly produced from t ...

Public Library of Science2008

Signaling downstream of the novel oncogene GNAQ in uveal melanoma

Lona Gaugler

[...] This report presents novel data following the discovery of somatic mutations in the heterotrimeric G protein alpha q subunit (GNAQ), found in 44% of uveal melanomas, 83% of blue nevi, and 50% of melanomas arising within blue nevi. [... click on "Down ...

2008

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor

David Michael Suter

Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylatio ...

American Society for Biochemistry and Molecular Biology2007

fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster

Pierre Gönczy

A number of fundamental processes comprise the cell division cycle, including spindle formation, chromosome segregation, and cytokinesis. Our current understanding of these processes has benefited from the isolation and analysis of mutants, with the meioti ...

2001

punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline

Pierre Gönczy

To identify regulators of stem cell lineages, we are focusing on spermatogenesis in Drosophila. In spermatogenesis, each germline stem cell divides asymmetrically, renewing itself and producing a transiently amplifying daughter, which divides four times. B ...

1997

bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis

Pierre Gönczy

Stem cells divide asymmetrically, regenerating a parental stem cell and giving rise to a daughter cell with a distinct fate. In many stem cell lineages, this daughter cell undergoes several amplificatory mitoses, thus generating more cells that embark on t ...

1997

Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development

The human beta-catenin locus (CTNNB1) was mapped by in situ fluorescence analysis to band p21 on the short arm of chromosome 3, a region frequently affected by somatic alterations in a variety of tumors. PCR primers for the genomic amplification of beta-ca ...

1994

Maternal repression of the P element promoter in the germline of Drosophila melanogaster: a model for the P cytotype

Bruno Lemaitre

The transposition of P elements in Drosophila melanogaster is regulated by products encoded by the P elements themselves. The P cytotype, which represses transposition and associated phenomena, exhibits both a maternal effect and maternal inheritance. The ...

Genetics Society of America1993

Somatic cell genetics and flow cytometry

Lukas Kühn

Human genes coding cell surface molecules can be introduced into mouse host cells using a variety of somatic cell genetic techniques. Because these human gene products can be detected using indirect immunofluorescence on viable cells, the genes themselves ...

1983

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