Concept

Lipid bilayer phase behavior

Publications associées (178)

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We propose and investigate a minimal mechanism that makes use of differential swelling to modify the critical buckling conditions of elastic bilayer shells, as measured by the knockdown factor. Our shells contain an engineered defect at the north pole and ...

ROYAL SOC CHEMISTRY2019

Molecular structure and function of myelin protein P0 in membrane stacking

Henning Paul-Julius Stahlberg

Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, this is partially enabled by myelin protein zero (P0). Consisting of an im ...

Springer Nature2019

Dynamic Imaging of Lipid Membranes by Means of Water

Orly Bagunu Tarun

Lipid membranes are self-assembled structures whose composition determines the properties of membranes of cells and organelles. The molecular level understanding of lipid membranes is based on spectroscopy and MD simulations of lipid monolayer systems. As ...

EPFL2019

Nanoparticle Liposome Interactions

Zekiye Pelin Güven

Protein-mimetic materials are of great interest for biotechnology to grant protein-like properties to artificial systems. Additionally, these materials can be used to shed light on the fundamental properties of proteins in many environments. Nanoparticles, ...

EPFL2018

Label-free and charge-sensitive dynamic imaging of lipid membrane hydration on millisecond time scales

Sylvie Roke, Orly Bagunu Tarun

Biological membranes are highly dynamic and complex lipid bilayers, responsible for the fate of living cells. To achieve this function, the hydrating environment is crucial. However, membrane imaging typically neglects water, focusing on the insertion of p ...

2018

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri

During their lifespan, Red blood cells (RBC), due to their inability to self-replicate, undergo an ageing degradation phenomenon. This pathway, both in vitro and in vivo, consists of a series of chemical and morphological modifications, which include devia ...

2018

Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor

Hatice Altug, George Coukos, Xiaokang Li, Aurélian Michel John-Herpin, Maria Soler Aznar

The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity and kinetics of a T cell receptor (TCR) binding to the peptide-major ...

AMER CHEMICAL SOC2018

Optical Antenna-Based Fluorescence Correlation Spectroscopy to Probe the Nanoscale Dynamics of Biological Membranes

Jürgen Brugger, Pamina Winkler, Valentin Flauraud, Raju Regmi

The plasma membrane of living cells is compartmentalized at multiple spatial scales ranging from the nano- to the mesoscale. This nonrandom organization is crucial for a large number of cellular functions. At the nanoscale, cell membranes organize into dyn ...

2018

Lipid exchange and signaling at ER–Golgi contact sites

Meticulous observations of the cell perinuclear region where the Golgi and the endoplasmic reticulum (ER) networks intermingle have revealed close contact sites of barely 20 nm between these two organelles. Recent studies demonstrate that molecular machine ...

2018

pH sensing by lipids in membranes: The fundamentals of pH-driven migration, polarization and deformations of lipid bilayer assemblies

Anne-Florence Raphaëlle Bitbol

Most biological molecules contain acido-basic groups that modulate their structure and interactions. A consequence is that pH gradients, local heterogeneities and dynamic variations are used by cells and organisms to drive or regulate specific biological f ...

Elsevier BV2018

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