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Colloidal drug and prodrug conjugates have unique targeting characteristics for tumor vasculature from the blood and for the lymphatics draining a tissue injection site. Tioguanine and tioguanine-generating prodrugs have been investigated as anticancer and ...
In this thesis, we proposed to study polymer-based thick-film resistors (TFRs) made of graphite particles dispersed in an epoxy matrix. Three main axes were investigated: formulation of the composites, characterization with the determination of electrical, ...
The lower critical solution temperature (LCST) behavior of novel poly(ethylene glycol) (PEG)-based copolymers bearing multiple functional groups, obtained by anionic ring-opening (co)polymerization (AROP), has been investigated. Variable comonomer ratios o ...
During the past decades the field of sensors has been subject to much attention due to an increased demand for (bio)sensors and environmental monitoring. The efforts have been concentrated to create sensors which are reliable, highly sensitive and selectiv ...
A high penetration grade bitumen has been blended with up to 50 wt% of two different grades of metallocene catalyzed linear low density polyethylene (m-LLDPE) in order to investigate the potential of these and similar copolymers as a substitute for styrene ...
Hydrogels are cross-linked, water-swollen polymer networks. Hydrogels with high mechanical and viscous dissipation properties are of great interest for mechanically control drug release systems. Since hydrogels are 3D polymer network with high amount of wa ...
The BaylisHillman reaction provides a protective-group-free strategy to heterobifunctional polyesters, which can be further modified via various post-polymerization modification reactions. This contribution explores the BaylisHillman polymerization of 1,3- ...
The residue-specific modification of peptides and proteins is a powerful strategy for preparing biomolecular-synthetic polymer conjugates with advanced properties. This manuscript aims at expanding the present toolbox of residue-selective protein modificat ...
Controlling the fate of stem cells in vitro is a key challenge towards using these cells in clinical applications. Adult stem cells (ASC) are known to reside in complex microenvironments called niches in vivo. These niches regulate stem cell fate providing ...
Aliphatic polyesters receive increasing attention over the last years driven by their application as biodegradable substitutes for conventional commodity thermoplastics and applications in the biomedical field, where amongst the family of biodegradable pol ...
