Publications associées à Leptine

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...

AMER PHYSIOLOGICAL SOC2019

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares, Blanca Lizarbe Serra

Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to ...

2019

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

Rolf Gruetter, João Miguel das Neves Duarte, Antoine Timothée Cherix, Blanca Lizarbe Serra, Jean-René Cardinaux

BACKGROUND/OBJECTIVES: High-fat diet consumption is known to trigger an inflammatory response in the hypothalamus, which has been characterized by an initial expression of pro-inflammatory genes followed by hypothalamic astrocytosis, microgliosis, and the ...

2019

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Johan Auwerx, Dongryeol Ryu

BACKGROUND & AIMS: Obesity-induced nonalcoholic fatty liver disease (NAFLD) develops, in part, via excess insulin-stimulated hepatic de novo lipogenesis, which increases, paradoxically, in patients with obesity-induced insulin resistance. Pleckstrin homolo ...

W B Saunders Co-Elsevier Inc2017

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Johan Auwerx, Dongryeol Ryu

Reduced mitochondria! electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded p ...

Rockefeller Univ Press2017

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Johan Auwerx, Evan Graehl Williams, Norman Lionel Moullan, Eija Riitta Pirinen

Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipi ...

American Diabetes Association2015

An Ex vivo Model to Study Hormone Action in the Human Breast

Cathrin Brisken, Georgios Sflomos

The study of hormone action in the human breast has been hampered by lack of adequate model systems. Upon in vitro culture, primary mammary epithelial cells tend to lose hormone receptor expression. Widely used hormone receptor positive breast cancer cell ...

Journal of Visualized Experiments2015

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Carlos Canto Alvarez, Joanna Ratajczak, Pablo Jose Fernandez Marcos

Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets ...

Elsevier Science Bv2015

Matrix-Assisted Transplantation of Functional Beige Adipose Tissue

Riccardo Sinisi, Grigory Karateev

Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 an ...

American Diabetes Association2015

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Leptine

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Motor and cognitive brain circuits of brain-machine interactions

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

An Ex vivo Model to Study Hormone Action in the Human Breast

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Matrix-Assisted Transplantation of Functional Beige Adipose Tissue

Graph Chatbot

Chattez avec Graph Search

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Motor and cognitive brain circuits of brain-machine interactions

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

Matrix-Assisted Transplantation of Functional Beige Adipose Tissue

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

An Ex vivo Model to Study Hormone Action in the Human Breast