Concept

Acide nucléique

Publications associées (113)

Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores

Aleksandra Radenovic, Matteo Dal Peraro, Chan Cao, Nuria Cirauqui Diaz, Alice Duperrex, Elena Buglakova

Nanopore sensing is a powerful single-molecule approach for the detection of biomolecules. Recent studies have demonstrated that aerolysin is a promising candidate to improve the accuracy of DNA sequencing and to develop novel single-molecule proteomic str ...

2019

Virus lasers for biological detection

Gabriel Aeppli

The selective amplification of DNA in the polymerase chain reaction is used to exponentially increase the signal in molecular diagnostics for nucleic acids, but there are no analogous techniques for signal enhancement in clinical tests for proteins or cell ...

Springer2019

Nature of Synergy between Bronsted and Lewis Acid Sites in Sn-Beta Zeolites for Polyoxymethylene Dimethyl Ethers Synthesis

Alimohammad Bahmanpour, Christophe Jean Baranowski

The role of Lewis and Bronsted acid sites and their potential synergy remains ambiguous for the production of polyoxymethylene dimethyl ethers (OME), which are suitable as a Diesel substitute. Here, this synergistic effect was investigated by using a serie ...

WILEY-V C H VERLAG GMBH2019

Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions

Henning Paul-Julius Stahlberg, Ling Zhang

The co-self-assembly of proteins and nucleic acids (NAs) produces complex biomolecular machines (e.g., ribosomes and telomerases) that represent some of the most daunting targets for biomolecular design. Despite significant advances in protein and DNA or R ...

American Chemical Society (ACS)2018

Scanning tunneling microscopy on large bio-molecular systems on surfaces

Sebastian Koslowski

The ever growing demand for the development of new technologies and materials has led to extensive studies inspired by biological functional complexes. Peptides with their outstanding ability to efficiently self-assemble can express a broad spectrum of int ...

EPFL2017

In and out—contribution of natural transformation to the shuffling of large genomic regions

Melanie Blokesch

Naturally competent bacteria can pull free DNA from their surroundings. This incoming DNA can serve various purposes, ranging from acting as a source of nutrients or DNA stretches for repair to the acquisition of novel genetic information. The latter proce ...

Elsevier2017

Spatial confinement induces hairpins in nicked circular DNA

Giovanni Dietler, Aleksandre Japaridze, Enzo Orlandini

In living cells, DNA is highly confined in space with the help of condensing agents, DNA binding proteins and high levels of supercoiling. Due to challenges associated with experimentally studying DNA under confinement, little is known about the impact of ...

Oxford University Press (OUP)2017

Interplay of Chemical and Electronic Structure on the Single-Molecule Level in 2D Polymerization

Klaus Kern, Claudius Morchutt, Carola Strasser

Single layers of covalently linked organic materials in the form of two-dimensional (2D) polymers constitute structures complementary to inorganic 2D materials. The electronic properties of 2D polymers may be manipulated through a deliberate choice of the ...

American Chemical Society2016

First-Principles Photoemission Spectroscopy of DNA and RNA Nucleobases from Koopmans-Compliant Functionals

Nicola Marzari, Giovanni Borghi, Andrea Ferretti

The need to interpret ultraviolet photoemission data strongly motivates the refinement of first-principles techniques that are able to accurately predict spectral properties. In this work, we employ Koopmans-compliant functionals, constructed to enforce pi ...

Amer Chemical Soc2016

Microfluidic device and method for isolation of nucleic acids

Bart Deplancke, Alina Isakova

The present invention concerns a microfluidic device for mechanically induced trapping of molecular interactions comprising at least a first unit cell and a second unit cell, each unit cell comprising - a membrane chamber comprising a membrane, - a flow ch ...

2016

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