Concept

Schistosoma mansoni

Publications associées (20)

Advancing first principle-based molecular dynamics of biological systems with machine learning

Molecular dynamics (MD) simulations have emerged as a transformative approach to analyse molecular systems at the atomic level, offering valuable insights into complex biological processes. Many biological phenomena can only accurately be described by inco ...

EPFL2023

Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles

Christian Iseli

All life forms on earth ultimately descended from a primordial population dubbed the last universal common ancestor or LUCA via Darwinian evolution. Extant living systems share two salient functional features, a metabolism extracting and transforming energ ...

2023

Gene drives for schistosomiasis transmission control

Francisco Javier Perez Saez

Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas. Although mass drug administr ...

2019

Modelled effects of prawn aquaculture on poverty alleviation and schistosomiasis control

Andrea Rinaldo, Lorenzo Mari, Francisco Javier Perez Saez, Marino Gatto

Recent evidence suggests that snail predators may aid efforts to control the human parasitic disease schistosomiasis by eating aquatic snail species that serve as intermediate hosts of the parasite. Here, potential synergies between schistosomiasis control ...

NATURE PUBLISHING GROUP2019

Space and time predictions of schistosomiasis snail host population dynamics across hydrologic regimes in Burkina Faso

Andrea Rinaldo, Theophile Mande, Francisco Javier Perez Saez

The ecology of the aquatic snails that serve as obligatory intermediate hosts of human schistosomiasis is driven by climatic and hydrological factors which result in specific spatial patterns of occurrence and abundance. These patterns in turn affect, join ...

2019

Comparative analysis of time-based and quadrat sampling in seasonal population dynamics of intermediate hosts of human schistosomes

Andrea Rinaldo, Theophile Mande, Francisco Javier Perez Saez

Background Despite their importance for designing and evaluating schistosomiasis control trials, little attention in the literature has been dedicated to sampling protocols for the parasite's snail intermediate hosts since their first development. We propo ...

2019

Targeting liver stage malaria with metformin

Leonardo Filipe Lemos Rocha

Despite an unprecedented 2 decades of success, the combat against malaria - the mosquito-transmitted disease caused by Plasmodium parasites - is no longer progressing. Efforts toward eradication are threatened by the lack of an effective vaccine and a rise ...

2019

Empirical Characterization of Particle Size Distribution Spatial Dynamics for Helminth Eggs Detection in Waste Stabilization Ponds (WSP)

Paolo Perona

This study assesses seasonal particle size distribution (PSD) dynamics inside a waste stabilization ponds (WSP) (Buguruni, Tanzania) to understand settling dynamics of wastewater particles with an interest in helminth eggs. Results indicate that particles ...

2018

Spatio-Temporal prediction of schistosomiasis infection in Burkina Faso

Thi Nhu Khanh Nguyen

Better model the spatial dynamics of the disease based on the available ecological and socio-economic data, combined with parasitological survey data and epidemiological reports ...

2017

Heterogeneity in schistosomiasis transmission dynamics

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Francisco Javier Perez Saez, Marino Gatto

Simple models of disease propagation often disregard the effects of transmission heterogeneity on the ecological and epidemiological dynamics associated with host-parasite interactions. However, for some diseases like schistosomiasis, a widespread parasiti ...

Academic Press Ltd- Elsevier Science Ltd2017

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