Concept

Schistosoma mansoni

Publications associées (20)

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nicolas Jean Philippe Guex, Nadine Fournier, Miguel Garcia, Etienne Meylan, Alessandra Piersigilli, Julien Robert Rémi Faget, Inti Zlobec, Gael Luis Boivin, Svenja Johanna Groeneveld, Loïc Steiner, Ioannis Xenarios

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1 + neutrophils to disease ...

Cell Press2017

Hydrology and density feedbacks control the ecology of intermediate hosts of schistosomiasis across habitats in seasonal climates

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Natalie Claire Ceperley, Theophile Mande, Francisco Javier Perez Saez, Marino Gatto

We report about field and theoretical studies on the ecology of the aquatic snails (Bulinus spp. and Biomphalaria pfeifferi) that serve as obligate intermediate hosts in the complex life cycle of the parasites causing human schistosomiasis. Snail abundance ...

Natl Acad Sciences2016

EFFECT OF WATER CONTACTS SEASONALITY ON SCHISTOSOMIASIS TRANSMISSION IN RURAL SAHELIAN AREA IN BURKINA FASO

Anna Faes

patterns due to economic and sociologic activities in African rural area are an important factor in the comprehension of the transmission of this disease. Through interviews and a participatory workshop, activities related to water-contact were identified, ...

2015

Rainfall Forecasting in Burkina Faso Using Bayesian-Wavelet Neural Networks

Jonathan Giezendanner

This work aims to forecast rain locally in Tambarga, Burkina Faso, to be able to fight against a worm inducing the disease called schistosomiasis. The chosen approach relies on a machine-leaning technique called Artificial Neural Networks, which simulates ...

2015

Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I

Arne Seitz, Romain Guiet, Duncan-Bruce Sutherland, Nicola Harris, Benjamin John Marsland, Beatrice Volpe, Julia Esser-von Bieren, Manuel Kulagin

Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helmin ...

Amer Assoc Immunologists2015

Geostatistical modelling for the monitoring of environmental-related endemic diseases: Application to the distribution of schistosomiasis in Burkina Faso

Laurent Hafiz

The increased interest of reducing the infection rates of neglected tropical diseases like schistosomiasis in the world has raised the necessity of developing epidemiological monitoring techniques, in order to target specific areas where the risk of infect ...

2014

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

Arne Seitz, Romain Guiet, Nicola Harris, Alessandra Piersigilli, Beatrice Volpe, Julia Esser-von Bieren, Ilaria Mosconi, Fei Chen

Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against chall ...

Public Library of Science2013

Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells

Nicola Harris, Raphaël Duvoisin

Blood flukes or schistosomes are the causative agents of human schistosomiasis, one of the major neglected tropical diseases. Draft genome sequences have been reported for schistosomes, but functional genomics tools are needed to investigate the role and e ...

2011

Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection

Nicola Harris, Andrew J. Macpherson

Anti-helminth immunity involves CD4+ T cells, yet the precise effector mechanisms responsible for parasite killing or expulsion remain elusive. We now report an essential role for antibodies in mediating immunity against the enteric helminth Heligmosomoide ...

2008

Production of Sm37-GAPDH, a major therapeutical target in human schistosomiasis

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the glycolytic metabolism and the production of energy. This probably explains why GAPDH was evidenced as a major therapeutical target in several parasitic diseases; either as a vaccine ca ...

Wiley-Blackwell2000

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