Concept
Gène homéotique
Publications associées (121)
A CTCF-dependent mechanism underlies the Hox timer relation to a segmented body plan
During gastrulation, Hox genes are activated in a timesequence that follows the order of the genes along their clusters. This property, which is observed in all animals that develop following a progressive rostral-to-caudal morphogenesis, is associated wit ...
Current Biology Ltd2024Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos
Denis Duboule, Lucille Delisle, Alexandre Gauthier Aurèle Mayran, Hocine Rekaik, Aurélie Hintermann, Célia Corinne Renée Bochaton
Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...
NATURE PORTFOLIO2023Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster
Denis Duboule, Lucille Delisle, Jozsef Zakany, Leonardo Beccari
In this study, Amandio et al. sought to understand the functions of the highly conserved CTCF sites distributed over the Hox gene clusters. The authors produced an allelic series of cumulative in cis mutations in these sites, up to the abrogation of CTCF b ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2021Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification
Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of HOX genes within axial stem cells that fuel axial embryo elongation. Whether HOX genes sequential activation, the “HOX clock”, is paced by intr ...
2020Patterning and mechanics of somite boundaries in zebrafish embryos
Andrew Charles Oates, Sundar Ram Naganathan
The body axis of vertebrates is subdivided into repetitive compartments called somites, which give rise primarily to the segmented architecture of the musculoskeletal system in the adult body. Somites form in a sequential and rhythmic manner in embryos and ...
2020