Concept

Virus de l'hépatite B

Publications associées (36)

Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Jacques Fellay, Bruno Emanuel Ferreira De Sousa Correia, Zhi Ming Xu, Andreas Scheck, Dylan Lawless, Olivier Noël Marie Naret, Arne Schneuing, David Gfeller, Thomas Junier, Sina Rüeger

Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host -induced selective pressure. Leveraging paired human exome and ultra -deep HBV genome-sequencing data from 567 affected individuals with chronic hepatitis B, we ...

Cell Press2024

Stimulus-responsive assembly of nonviral nucleocapsids

Angela Steinauer

Controlled assembly of a protein shell around a viral genome is a key step in the life cycle of many viruses. Here we report a strategy for regulating the co-assembly of nonviral proteins and nucleic acids into highly ordered nucleocapsids in vitro. By fus ...

Nature Portfolio2024

Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus

Myriam Isabelle Lamrayah

Hepatitis B virus remains a major medical burden with more than 250 million chronically infected patients worldwide and 900,000 deaths each year, due to the disease progression towards severe complications (cirrhosis, hepatocellular carcinoma). Despite the ...

ELSEVIER2023

Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Jacques Fellay, Christian Hammer, Nimisha Chaturvedi, Petar Scepanovic, Samira Asgari

Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...

2019

Population density and water balance influence the global occurrence of hepatitis E epidemics

Stéphane Joost, Anna Carratala Ripolles

In developing countries, the waterborne transmission of hepatitis E virus (HEV), caused by HEV genotypes 1 (HEV-1) and 2 (HEV-2), leads to the onset of large recurrent outbreaks. HEV infections are of particular concern among pregnant women, due to very hi ...

2019

Population density and water balance influence the global occurrence of hepatitis E epidemics

Stéphane Joost, Anna Carratala Ripolles

In developing countries, the waterborne transmission of hepatitis E virus (HEV), particularly the genotypes 1 and 2, leads to the onset of large recurrent outbreaks. In order to identify the geographical regions at higher risk of HEV epidemics and the cond ...

2018

Integration of the role of climate in the spatial modeling of waterborne hepatitis E virus

Stéphane Joost, Anna Carratala Ripolles

Hepatitis E virus (HEV) is among the major causes of acute viral hepatitis worldwide. In developing countries, HEV infections are caused by genotypes 1 and 2, due to consumption of contaminated water. Large and recurrent outbreaks of HEV occur in specific ...

2017

Modeling the present and future distribution of waterborne Hepatitis E virus

Stéphane Joost, Anna Carratala Ripolles

Hepatitis E is among the major causes of acute viral hepatitis worldwide. Infections occurring in industrialized countries are caused by zoonotic genotypes 3 and 4, mostly due to the consumption of raw meat products such as pork liver, wild boar and deer m ...

2017

Assessment of the correlation among antibiotic resistance, adherence to abiotic and biotic surfaces, invasion and cytotoxicity of Pseudomonas aeruginosa isolated from diseased gilthead sea bream

Sami Rtimi

Improper uses of antibiotics to treat fish disease pose an increase of multidrug resistance in Pseudomonas aeruginosa. In order to escape host antimicrobial agents and induce cytotoxicity, different virulence properties are needed by these bacteria such as ...

Elsevier2017

Contribution of recombination to the evolutionary history of HIV

Séverine Vuilleumier Varisco

Purpose of review: An improved understanding of how recombination affects the evolutionary history of HIV is crucial to understand its current and future evolution. The present review aims to disentangle the manifold effects of recombination on HIV by disc ...

2015

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