Concept
Ligand (biologie)
Publications associées (451)
Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold
Attempts to create novel ligand-binding proteins often focus on formation of a binding pocket with shape complementarity against the desired ligand (particularly for compounds that lack distinct polar moieties). Although designed proteins often exhibit bin ...
OXFORD UNIV PRESS2018Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2
Dectin-2 is a C-type lectin involved in the recognition of several pathogens such as Aspergillus fumigatus, Candida albicans, Schistosoma mansonii, and Mycobacterium tuberculosis that triggers Th17 immune responses. Identifying pathogen ligands and underst ...
NATURE PUBLISHING GROUP2018Explore RdhK based regulatory network of organohalide respiration using a hybrid proteins strategy
Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin
Reductive dehalogenase (rdh) gene clusters encode for proteins involved in organohalide respiration (OHR), a bacterial process where organohalide compounds are used as terminal electron acceptors. RdhK proteins, members of the CRP/FNR family of transcripti ...
2018Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states
ABCG2 is a transporter protein of the ATP-binding-cassette (ABC) family that is expressed in the plasma membrane in cells of various tissues and tissue barriers, including the blood-brain, blood-testis and maternal-fetal barriers(1-4). Powered by ATP, it t ...
Springer Nature America, Inc2018Mapping affinities: visualizing academic practice through collaboration
Academic affinities are one of the most fundamental hidden dynamics that drive scientific development. Some affinities are actual, and consequently can be measured through classical academic metrics such as co-authoring. Other affinities are potential, and ...
EPFL2018The cold denaturation of IscU highlights structure–function dualism in marginally stable proteins
Proteins undergo both cold and heat denaturation, but often cold denaturation cannot be detected because it occurs at temperatures below water freezing. Proteins undergoing detectable cold as well as heat denaturation yield a reliable curve of protein stab ...
2018Coexistence of two distinct Sulfurospirillum populations respiring tetrachloroethene—genomic and kinetic considerations
Christof Holliger, Julien Maillard, Géraldine Florence Buttet, Alexandra Marie Murray, Mélissa Burion
Two anaerobic bacterial consortia, each harboring a distinct Sulfurospirillum population, were derived from a 10 year old consortium, SL2, previously characterized for the stepwise dechlorination of tetrachloroethene (PCE) to cis-dichloroethene (cis-DCE) v ...
FEMS Microbiology Ecology, Vol. 94, Issue 12018