Publications associées à Wee1

Anti-angiogenic properties of chlorambucil derivatives with fluorous and hydrocarbon appendages

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Chlorambucil (CLB) derivatives with long fluorous (referred to as 1 and 2) or hydrocarbon (3) chains have been evaluated in a series of in vitro and in vivo assays. In cell viability inhibition assays, both derivatives 2 and 3 show selective cytotoxicity t ...

Royal Society of Chemistry2016

An Extended, Boolean Model of the Septation Initiation Network in S-pombe Provides Insights into Its Regulation

Viesturs Simanis, Andrea Krapp, Elena Cano, Anastasia Chasapi, Ioannis Xenarios

Cytokinesis in fission yeast is controlled by the Septation Initiation Network (SIN), a protein kinase signaling network using the spindle pole body as scaffold. In order to describe the qualitative behavior of the system and predict unknown mutant behavio ...

Public Library of Science2015

Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array

Sebastian Maerkl, Jean-Bernard Nobs

Although Schyzosaccharomyces pombe is one of the principal model organisms for studying the cell cycle, surprisingly few methods have characterized S. pombe growth on the single cell level, and no methods exist capable of analyzing thousands of cells and t ...

Public Library of Science2014

Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast

Viesturs Simanis, Andrea Krapp

Activation of mitosis-promoting factor (MPF) drives mitotic commitment. In human cells active MPF appears first on centrosomes. We show that local activation of MPF on the equivalent organelle of fission yeast, the spindle pole body (SPB), promotes Polo ki ...

Nature Publishing Group2013

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

Pierre Gönczy, Coralie Busso, Sachin Kotak

Spindle positioning and spindle elongation are critical for proper cell division. In human cells, an evolutionary conserved ternary complex (NuMA/LGN/Gαi) anchors dynein at the cortex during metaphase, thus ensuring correct spindle positioning. Whether thi ...

Nature Publishing Group2013

A 2D/3D image analysis system to track fluorescently labeled structures in rod-shaped cells: application to measure spindle pole asymmetry during mitosis

Michaël Unser, Daniel Sage, Viesturs Simanis, Daniel Andreas Schmitter, Anastasia Chasapi, Ioannis Xenarios

Background: The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by a network of signaling proteins ...

Biomed Central Ltd2013

The Brucella pathogens are polarized bacteria

Charles Ulric V Van der Henst

Brucella pathogens are responsible for brucellosis, a worldwide zoonosis. They are facultative intracellular pathogens characterized by their asymmetric division and their unipolar growth. This growth modality generates poles with specialized functions (th ...

Elsevier Science Bv2013

The S-pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1

Viesturs Simanis

Mitotic exit integrates the reversal of the phosphorylation events initiated by mitotic kinases with a controlled cytokinesis event that cleaves the cell in two. The mitotic exit network (MEN) of budding yeast regulates both processes, whereas the fission ...

Nature Publishing Group2012

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Wee1

Anti-angiogenic properties of chlorambucil derivatives with fluorous and hydrocarbon appendages

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

An Extended, Boolean Model of the Septation Initiation Network in S-pombe Provides Insights into Its Regulation

Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array

Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

A 2D/3D image analysis system to track fluorescently labeled structures in rod-shaped cells: application to measure spindle pole asymmetry during mitosis

The Brucella pathogens are polarized bacteria

MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression

The S-pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1

Graph Chatbot

Chattez avec Graph Search

The Brucella pathogens are polarized bacteria

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

Anti-angiogenic properties of chlorambucil derivatives with fluorous and hydrocarbon appendages

An Extended, Boolean Model of the Septation Initiation Network in S-pombe Provides Insights into Its Regulation

Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast

A 2D/3D image analysis system to track fluorescently labeled structures in rod-shaped cells: application to measure spindle pole asymmetry during mitosis

MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression

The S-pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1