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The Ecole Polytechnique Fédérale de Lausanne is a science and technology university building its « Rolex Learning Center », which will be inaugurated in 2010. Point of entry to EPFL, the Rolex Learning Center (RLC) will be a place where people canl learn, ...
Bicyclic peptide ligands are promising molecules for the development of new therapeutics. They combine advantages from large protein therapeutics and small molecule drugs. Large combinatorial libraries of bicyclic peptides can be generated and screened by ...
The continuous progress in medicinal chemistry requires more versatile synthetic strategies for the generation of large libraries of active compounds and their analogues. As a result, the research for new effective cyclization and cycloaddition reactions i ...
In recent years, funding agencies, governments, and international organization have issued a series of research data management and sharing policies, like the H2020 [1]. Researchers are encouraged or required to share their production in an open way, inclu ...
Machine learning has been largely applied to ana- lyze data in various domains, but it is still new to personalized medicine, especially dose individualization. In this paper, we focus on the prediction of drug concentrations using Support Vector Machines ...
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Numerous libraries and museums hold large art historical photographic collections, numbering millions of images. Because of their non-standard format, these collections pose special challenges for digitization. This paper address these difficulties by prop ...
Computational multiscale methods such as the FE2 technique (Feyel, 1999) come along with large demands in both CPU time and memory. In order to significantly reduce the computational cost of multiscale methods the authors recently proposed a hybrid computa ...
Microarrays allowing simultaneous analysis of thousands of parameters can significantly accelerate screening of large libraries of pharmaceutical compounds and biomolecular interactions. For large-scale studies on diverse biomedical samples, reliable, labe ...
Macrophage Migration Inhibitory Factor (MIF) is a multifunctional protein and a major mediator of innate immunity. The paramount importance of MIF in the pathogenesis of many inflammatory, infectious, auto-immune and oncogenic diseases led to its emergence ...
Many collection development practices are relevant for electronic books as well as for their paper counterparts: selection, acquisition, management, cataloguing, evaluation, etc. Over the years, libraries have developed best practices and tools to tackle t ...
