Concept

Maladie de Parkinson

Publications associées (213)

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, includin ...

Public Library of Science2010

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

Hilal Lashuel, Patrick Aebischer, Bernard Schneider, Diego Chiappe, Marc Moniatte, Adrian Schmid, Magdalena Zweckstetter, Abid Oueslati

Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease. Herein we demonstrate that alpha-syn is p ...

2010

The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species

Hilal Lashuel, Saviana Di Giovanni

Parkinson's disease (PD) is a movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of intraneuronal inclusions called Lewy bodies, which are composed mainly of α-synuclein (α-syn). Selegiline (Sel) i ...

2010

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research

Hilal Lashuel, Mohammad Asad Jan Qureshi

The amyloid cascade hypothesis, supported by strong evidence from genetics, pathology and studies using animal models, implicates amyloid-beta (Abeta) oligomerization and fibrillogenesis as central causative events in the pathogenesis of Alzheimer's diseas ...

Nature Publishing Group2010

Gaze quality assisted automatic recognition of social contexts in collaborative Tetris

Patrick Jermann, Weifeng Li, Marc-Antoine Nüssli

The use of dual eye-tracking is investigated in a collabora- tive game setting. Social context influences individual gaze and action during a collaborative Tetris game: results show that experts as well as novices adapt their playing style when interacting ...

2010

Advanced oxidation of the surfactant SDBS by means of hydroxyl and sulphate radicals

Urs von Gunten, Silvio Canonica

The objective of the present study was to characterize the removal of the model surfactant sodium dodecylbenzene sulfonate (SDBS) from waters using several radical-based water treatment processes. Fenton's reagent has shown high efficacy in surfactant degr ...

2010

Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

Darren Moore

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common causes of both familial and sporadic forms of Parkinson disease and are also associated with diverse pathological alterations. The mechanisms whereby LRRK2 mutations ca ...

2009

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

Hilal Lashuel

In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recess ...

Public Library of Science2009

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

Michaël Unser, Patrick Aebischer, Bernard Schneider, Daniel Sage, Samareh Azeredo da Silveira Lajaunias

Phosphorylation is involved in numerous neurodegenerative diseases. In particular, alpha-synuclein is extensively phosphorylated in aggregates in patients suffering from synucleinopathies. However, the share of this modification in the events that lead to ...

Oxford University Press2009

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

Patrick Aebischer

We explored the relationship between ubiquitin proteasome system (UPS) and lysosomal markers and the formation of alpha-synuclein (alpha-syn) inclusions in nigral neurons in Parkinson disease (PD). Lysosome Associated Membrane Protein 1(LAMP1), Cathepsin D ...

2009

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