Concept
Aster (biologie)
Publications associées (55)
Centromere structure and function: lessons from Drosophila
The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing our understanding of biological processes, not just by studying its similarities with other organisms including ourselves but also by investigating its differences to u ...
Bethesda2023CENP-A and CENP-B collaborate to create an open centromeric chromatin state
Beat Fierz, Wei Cai, Harsh Nagpal
Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the centromere to spindle microtubules d ...
Berlin2023Mapping of real-time morphological changes in the neuronal cytoskeleton with label-free wide-field second-harmonic imaging: a case study of nocodazole
Sylvie Roke, Carlos Alberto Macias Romero, Pascal Jourdain, Marie Eve Pascale Didier, Claire Jacqueline Léa Teulon
We demonstrate the use of wide-field high-throughput second-harmonic (SH) microscopy for investigating cytoskeletal morphological changes on the single-cell level. The method allows for real-time, in vitro, label-free measurements of cytoskeletal changes t ...
SPIE-Intl Soc Optical Eng2019Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
Hilal Lashuel, Mahmood Haj Yahya
The microtubule-associated protein Tau plays a central role in neurodegeneration and is a leading therapeutic target for the treatment of Alzheimer’s disease (AD). Several lines of evidence suggest that post-translational modifications (PTMs) regulate the ...
2018Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes
Pierre Gönczy, Alessandro De Simone
Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces ...
Amer Soc Cell Biology2017Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells
Pierre Gönczy, Coralie Busso, Sachin Kotak
Accurate spindle positioning is essential for error-free cell division. The one-cell Caenorhabditis elegans embryo has proven instrumental for dissecting mechanisms governing spindle positioning. Despite important progress, how the cortical forces that act ...
2016