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Gene therapy is an attractive approach for the treatment of a wide spectrum of liver diseases. Lentiviral vectors allow the stable integration of transgenes into the genome of nondividing differentiated cells including hepatocytes and could provide long-la ...
Dissection of complex processes using model organisms such as yeasts relies heavily upon the use of conditional mutants. We have generated a collection of fission yeast mutants sensitive to dimethylsulphoxide (DMSO). Among these we have found a mutant in t ...
The goal of this thesis is to develop new carbon-carbon bond forming reactions using inexpensive and simple coupling partners like aryl halides (pseudohalides), sulfonyl derivatives, Grignard reagents, alkenes and alkynes with metal catalysis, preferably u ...
The Diels-Alder adduct of 2,4-dimethylfuran to 1-cyanovinyl (1'S)-camphanate was converted into (2R,3R,4S,5S,6R,7R)-3,6-epoxy-4,5-isopropylidenedioxy-2,4,6-trimethyl-7- [(tert-butyl)-dimethylsilyloxy]non-1-yl phenyl sulfoxides (6), the condensation of whic ...
The reaction of (cymene)RuCl2 (1) with PCY3 was investigated using different stoichiometries and reaction conditions. Whereas a mixture of complex 1 and 2 equiv of PCy3 in methanol gave the known adduct [(cymene)Rucl(2)(PCy3)] (3) along with the phosp ...
Hydroformylation of vinyl arenes (p-metboxystyrene and p-fluorostyrene) was performed in aqueous solutions using as catalyst precursor Rh(mu-OMe)(cod) (cod = 1,5-cyclooctadiene) associated with the sulfonated 1,3-diarylphosphines (tetra-sulfonated 1,3 ...
Adding a potent antioxidant, glutathione (GSH), to a cryoprotective solution consisting of dimethyl sulfoxide and ethylene glycol and/or postthaw culture medium significantly improved the postthaw viability of mouse embryonic stem cells. This effect, which ...
In the presence of iron(II) chloride (FeCl2 ; 20 mol%) and potassium tert-butoxide (t- BuOK; 4 equiv.) in dimethyl sulfoxide (DMSO), aryl and heteroaryl iodides undergo stereoselective Mizoroki–Heck C—C cross-coupling reactions with styrenes at 60 8C givin ...
In this work, we report thermoelectric measurements on electroplated bismuth telluride nanowires. Porous polycarbonate membranes, obtained by ion-track irradiation lithography, were chosen as electroplating templates. Bismuth telluride nanowires were achie ...