Concept

Ventricular remodeling

Publications associées (77)

Numerical Solution of the Monodomain Equation: an Inverse Problem for Infarction Models

This project deals with the ﬁnite element approximation of an inverse problem for the monodomain equation, which models the propagation of the electrical potential in the cardiac muscle. The goal consists in recovering the shape of an infarcted area inside ...

2012

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

Jeffrey Alan Hubbell

We present use of a synthetic, injectable matrix metalloproteinase (MMP)- responsive, bioactive hydrogel as an in situ forming scaffold to deliver thymosin beta 4 (T beta 4), a pro-angiogenic and pro-survival factor, along with vascular cells derived from ...

2011

Mechano-electrical contribution of ventricular contractions to the complexity of atrial fibrillation electrograms

Jean-Marc Vesin, Andréa Buttu, Etienne Pruvot, Sarah Volorio

Purpose: Intracardiac organization indices (OI) have been used to track the efficiency of stepwise radiofrequency catheter ablation (step-CA) of persistent atrial fibrillation (pers-AF). A better understanding of the components and complexity of AF electro ...

2011

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

Richardus Houtkooper

Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, and neutropenia. Tafazzin is a mitochondrial transacylase requ ...

2011

On some numerical aspects of an active strain model in cardiac mechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Simone Rossi

We are interested in the development, implementation and testing of an orthotropic model for cardiac contraction based on an active strain decomposition. Our model addresses the coupling of a transversely isotropic mechanical description at the cell level, ...

Wiley2011

Bio Simulation of Brain Ventricle Dilation in Normal Pressure Hydrocephalus

Kamal Shahim

Hydrocephalus is a brain disease wherein the ventricles dilate and compress the parenchyma towards the skull. It is primarily characterized by the disruption of the cerebrospinal fluid (CSF) flow within the ventricular system. Normal pressure hydrocephalus ...

EPFL2011

Electromechanical Coupling In Cardiac Dynamics: The Active Strain Approach

Alfio Quarteroni, Fabio Nobile

The coupling between cardiac mechanics and electric signaling is addressed in a nonstandard framework in which the electrical potential dictates the active strain (not stress) of the muscle. The physiological and mathematical motivations leading us to this ...

Society for Industrial and Applied Mathematics2011

A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: Development, characterization, and applications

Melody Swartz, Jan Overney, James Brandon Dixon, Adrian Chung-Kai Shieh, Carmen Bonvin

Interstitial flow is an important biophysical cue that can affect capillary morphogenesis, tumor cell migration, and fibroblast remodeling of the extracellular matrix, among others. Current models that incorporate interstitial flow and that are suitable fo ...

Wiley-Blackwell2010

Arterial remodeling using a constituent-based approach

Alkiviadis Tsamis

This thesis is intended to contribute to the field of biomechanics of growth and remodeling of arteries. The work focuses particularly on growth and remodeling caused by sustained hypertension, increased blood flow, and ageing. A structure-based constituti ...

EPFL2010

A structure-based model of arterial remodeling in response to sustained hypertension

Nikolaos Stergiopoulos, Alkiviadis Tsamis, Alexander Rachev

A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow- ...

2009

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