Concept
Hypokinesia
Publications associées (40)
Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia
Objective: Depotentiation of homosynaptic plasticity of the primary motor cortex (M1) is impaired in patients with Parkinson's disease (PD) who have developed dyskinesias. In this exploratory study, we tested whether this holds true for heterosynaptic plas ...
ELSEVIER SCI LTD2022Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity
Kamiar Aminian, Farzin Dadashi, Benoît Mariani, Arash Atrsaei
Gait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions prov ...
2021Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing
Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl
Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...
CELL PRESS2021On Modeling Glottal Source Information for Phonation Assessment in Parkinson's Disease
Mathew Magimai Doss, Julian David Fritsch
Parkinson's disease produces several motor symptoms, including different speech impairments that are known as hypokinetic dysarthria. Symptoms associated to dysarthria affect different dimensions of speech such as phonation, articulation, prosody, and inte ...
ISCA-INT SPEECH COMMUNICATION ASSOC2021Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease
Accurate assessment of Parkinson’s disease (PD) ON and OFF states in the usual environment is essential for tailoring optimal treatments. Wearables facilitate measurements of gait in novel and unsupervised environments; however, differences between unsupe ...
2021MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning
Tobias Kober, Bénédicte Marie Maréchal
Background: Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concen ...
ELSEVIER2020A computational biophysical model of thalamic and reticular nucleus microcircuitry: from neurons to emergent network dynamics
The thalamus, once believed to be a simple relay station between the body periphery and the neocortex, has started to be recognized as a key player in higher-order functions, such as attention. It participates in the transition between brain states, such a ...
EPFL2020