Publications associées à Mitotic catastrophe

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

Pierre Gönczy, Maria Josefina Marcaida Lopez, Sachin Kotak, Jean-Louis Reymond

Here we report the discovery of a selective inhibitor of Aurora A, a key regulator of cell division and potential anticancer target. We used the atom category extended ligand overlap score (xLOS), a 3D ligand-based virtual screening method recently develop ...

2016

Cortical neurons gradually attain a post-mitotic state

Johannes Gräff

Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. Here we ...

Inst Biochemistry & Cell Biology2016

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Pierre Gönczy, Coralie Busso, Sachin Kotak

Accurate spindle positioning is essential for error-free cell division. The one-cell Caenorhabditis elegans embryo has proven instrumental for dissecting mechanisms governing spindle positioning. Despite important progress, how the cortical forces that act ...

2016

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Pierre Gönczy, Alessandro De Simone

The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...

Elsevier2016

Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth

Pierre Gönczy, Nicola Jane Dynes, Ashwani Sharma

Centrioles are fundamental and evolutionarily conserved microtubule-based organelles whose assembly is characterized by microtubule growth rates that are orders of magnitude slower than those of cytoplasmic microtubules. Several centriolar proteins can int ...

2016

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation

Suliana Manley, David Michael Suter, Marion Leleu, Cédric Deluz, Aleksandr Benke, Andrea Callegari, Torgil Elias Friman, Mahé Cécile Raccaud, Daniel Strebinger

Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and were proposed to regulate phenotypic maintenance of stem and progenitor cells at the mitosis-to-G1 (M-G1) transition. However, mitotic bookmarking remains largely unex ...

Cold Spring Harbor Laboratory2016

Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN

Michaël Unser, Daniel Sage, Jacques Rougemont, Viesturs Simanis, Andrea Krapp, Daniel Andreas Schmitter, Anastasia Chasapi, Ioannis Xenarios

The Schizosaccharomyces pombe septation initiation network (SIN) regulates cytokinesis, and asymmetric association of SIN proteins with the mitotic spindle pole bodies (SPBs) is important for its regulation. Here, we have used semi-automated image analysis ...

Company Of Biologists Ltd2015

Pombe's thirteen - control of fission yeast cell division by the septation initiation network

Viesturs Simanis

The septation initiation network (SIN) regulates aspects of cell growth and division in Schizosaccharomyces pombe and is essential for cytokinesis. Insufficient signalling results in improper assembly of the contractile ring and failure of cytokinesis, gen ...

Company Of Biologists Ltd2015

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Mitotic catastrophe

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

Cortical neurons gradually attain a post-mitotic state

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Eukaryotic transcription factor binding kinetics

Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth

Mechanisms of centrosome separation in C. elegans

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation

Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN

Pombe's thirteen - control of fission yeast cell division by the septation initiation network

Graph Chatbot

Chattez avec Graph Search

Eukaryotic transcription factor binding kinetics

Pombe's thirteen - control of fission yeast cell division by the septation initiation network

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

Cortical neurons gradually attain a post-mitotic state

Mechanisms of centrosome separation in C. elegans

Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation