Concept

Phosphorylation oxydative

Publications associées (383)

RdhC, a family of membrane-bound flavoproteins involved in electron transfer in organohalide respiration ?

Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin, Géraldine Florence Buttet

Organohalide respiration (OHR) is a bacterial energy metabolism making use of halogenated compounds – like tetrachloroethene (PCE), a major pollutant – as terminal electron acceptors. Three models of electron transport chain exist for OHR [1], however many ...

2018

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

Hilal Lashuel, Juan Kiwi, Bruno Claude Daniel Fauvet, Anass Chiki, Farah El Turk

Intracellular deposits of α-synuclein in the form of Lewy bodies are major hallmarks of Parkinson’s disease (PD) and a range of related neurodegenerative disorders. Post-translational modifications (PTMs) of α-synuclein are increasingly thought to be major ...

2018

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

Henning Paul-Julius Stahlberg

ABCG2 is a transporter protein of the ATP-binding-cassette (ABC) family that is expressed in the plasma membrane in cells of various tissues and tissue barriers, including the blood-brain, blood-testis and maternal-fetal barriers(1-4). Powered by ATP, it t ...

Springer Nature America, Inc2018

Redox Signaling by Reactive Electrophiles and Oxidants

Yimon Aye, Jesse Poganik

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and mul ...

2018

Semisynthetic Biosensors for the Quantification of Nicotinamide Adenine Dinucleotides in Live Cells

Olivier Vincent Sallin

Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are crucial redox cofactors regulating energy metabolism, reductive biosynthesis and the antioxidant defense system. Besides their role as redox cofactors, NAD(P ...

EPFL2018

Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins

Paolo De Los Rios, Alessandro Barducci, Pierre Goloubinoff, Bruno Claude Daniel Fauvet, Alberto Stefano Sassi

During and after protein translation, molecular chaperones require ATP hydrolysis to favor the native folding of their substrates and, under stress, to avoid aggregation and revert misfolding. Why do some chaperones need ATP, and what are the consequences ...

2018

An energetic view of stress: Focus on mitochondria

Maria del Carmen Sandi Perez

Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is largely derived from mitochondria – unique multifunctional organelles with their own genome. Four main elements connect mitochondria to stress: 1) Energy is r ...

2018

Maldi device and methods of preparation and use thereof

Hubert Girault, Horst Pick, Milica Jovic, Yingdi Zhu

A target plate for enhanced matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) analysis of intact biological entities. The target plate comprises an electrically conductive substrate (1) covered at least partially with immobilised pho ...

2018

Reactions of Ferrate(VI) with Iodide and Hypoiodous Acid: Kinetics, Pathways, and Implications for the Fate of Iodine during Water Treatment

Urs von Gunten, Yun Ho Lee, Jaedon Shin

Oxidative treatment of iodide-containing waters can form toxic iodinated disinfection byproducts (I-DBPs). To better understand the fate of iodine, kinetics, products, and stoichiometries for the reactions of ferrate(VI) with iodide (I-) and hypoiodous aci ...

2018

Polymer-Brush-Templated Three-Dimensional Molybdenum Sulfide Catalyst for Hydrogen Evolution

Harm-Anton Klok, Xile Hu, Heron Vrubel, Piotr Mocny, Lucas-Alexandre Stern, Tugba Bilgiç Tune

Earth-abundant hydrogen evolution catalysts are essential for high-efficiency solar-driven water splitting. Although a significant amount of studies have been dedicated to the development of new catalytic materials, the microscopic assembly of these materi ...

2018

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