Concept
Amoeboid movement
Publications associées (40)
Analysis and Modeling of the Dynamics of Traction Forces during Cell Polarization and their Role in the Organization of Edge Activity
The capacity to break symmetry and organize activity to move directionally is a fundamental property of eukaryotic cells. To explain the organization of cell-edge activity, models commonly rely on front-to-back gradients of functional components or regulat ...
EPFL2021Buckling instabilities and spatio-temporal dynamics of active elastic filaments
Biological filaments driven by molecular motors tend to experience tangential propulsive forces also known as active follower forces. When such a filament encounters an obstacle, it deforms, which reorients its follower forces and alters its entire motion. ...
ROYAL SOC2020Traction Forces Control Cell-Edge Dynamics and Mediate Distance Sensitivity during Cell Polarization
Franck Claude Raynaud, Alicia Carine Bornert, Zeno Messi
Traction forces are generated by cellular actin-myosin system and transmitted to the environment through adhesions. They are believed to drive cell motion, shape changes, and extracellular matrix remodeling [1 -3] . However, most of the traction force anal ...
2020Glutaredoxin1 Diminishes Amyloid Beta-Mediated Oxidation of F-Actin and Reverses Cognitive Deficits in an Alzheimer's Disease Mouse Model
Aims: Reactive oxygen species (ROS) generated during Alzheimer's disease (AD) pathogenesis through multiple sources are implicated in synaptic pathology observed in the disease. We have previously shown F-actin disassembly in dendritic spines in early AD ( ...
2019Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes
Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva
The protein acyl transferase ZDHHC5 was recently proposed to regulate trafficking in the endocytic pathway. Therefore, we explored the function of this enzyme in controlling the action of bacterial toxins. We found that ZDHHC5 activity is required for two ...
2019Pseudomonas aeruginosa orchestrates twitching motility by sequential control of type IV pili movements
Alexandre Louis André Persat, Lorenzo Anton-Louis Talà
Prokaryotes have the ability to walk on surfaces using type IV pili (TFP), a motility mechanism known as twitching(1,2). Molecular motors drive TFP extension and retraction, but whether and how these movements are coordinated is unknown(3). Here, we reveal ...
NATURE PUBLISHING GROUP2019Morphogenetic degeneracies in the actomyosin cortex
One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, where large-scale ...
ELIFE SCIENCES PUBLICATIONS LTD2018