Concept

Acide polylactique

Publications associées (126)

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Davide Demurtas, Jeffrey Alan Hubbell, Conlin O'Neil, Andrija Finka

One of the major engineering challenges for the implementation of block copolymer vesicles, or polymersomes, as therapeutic drug carriers is obtaining high encapsulation efficiencies for biomolecules. Here we present it novel method for encapsulation of pr ...

2009

Cellular composites based on continuous fibres and bioresorbable polymers

Pierre-Etienne Bourban

Biocompatible composites, whose porosity and fibre fraction call be tailored over a large range and whose mechanical resistance is comparable to that Of natural bone, were processed with poly(lactic acid) (PLA) and continuous glass fibres. The processing s ...

2008

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban, Corinne Scaletta, Claire Diane Delabarde

Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promot ...

2008

Processing of fibre and porosity gradients in cellular thermoplastic composites

Manuel Bühler

The aim of this study has been to develop processing techniques for novel bioresorbable thermoplastic cellular composites, reinforced with continuous inorganic fibres, for use as biodegradable scaffolds for bone tissue engineering. As the implanted composi ...

EPFL2008

Cellular thermoplastic composites with microstructural gradients of fibres and porosity

Pierre-Etienne Bourban, Manuel Bühler

New thermoplastic composites with their composition tailored at the yarn level were proposed and successfully prepared. A specific processing method was developed for composites exhibiting different fibre and porosity concentration gradients. Mechanical pr ...

2008

Polylactic acid-phosphate glass composite foams as scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban

Phosphate glass (PG) of the composition 0.46(CaO)-0.04(Na(2)O)- 0.5(P(2)O(5)) was used as filler in poly-L-lactic acid (PLA) foams developed as degradable scaffolds for bone tissue engineering. The effect of PG on PLA was assessed both in bulk and porous c ...

2007

A composite biofoam, from research to in vivo validation

Dominique Pioletti, Pierre-Etienne Bourban

Bone tissue engineering aims at developing scaffolds, or porous structures, as supports for cell migration, proliferation and differentiation, in order to favor bone healing. L-poly lactic acid (PLA) foams, which were reinforced or not with β-tricalcium ph ...

2007

Optimization of hybrid thermoplastic composite structures using surrogate models and genetic algorithms

Martyn Douglas Wakeman

Using an integrated processing methodology, an injection or compression moulded thermoplastic structure can be locally reinforced, for example, with textile structures or uni-directional fibre tows. Netshape components can be produced with cycle times typi ...

2007

Bulk synthesis of transparent and homogeneous polymeric hybrid materials with ZnO quantum dots and PMMA

Yun Suk Jo

In situ sol-gel polymerization is demonstrated for fabricating transparent poly(methyl methacrylate) (PMMA)-ZnO quantum dot (QD)- hybrid materials in bulk dimension. The transparent PMMA-ZnO QD hybrid materials exhibit enhanced UV-shielding effects in the ...

2007

Fabrication and testing of a poly(vinylidene fluoride) (PVDF) microvalve for gas flow control

Jürgen Brugger

A microactuator made from poly(vinylidene fluoride) (PVDF), a piezoelectric polymer, was fabricated to control the gas flow rate through a glass micronozzle. The actuator was formed by gluing together two PVDF sheets with opposite polarization directions. ...

2007

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