Concept

Facteur de croissance nerveuse

Publications associées (126)

Synergistic NGF/B27 Gradients Position Synapses Heterogeneously in 3D Micropatterned Neural Cultures

Philippe Renaud, Dominique Zosso, Ana Valero, Anja Kunze

Native functional brain circuits show different numbers of synapses (synaptic densities) in the cerebral cortex. Until now, different synaptic densities could not be studied in vitro using current cell culture methods for primary neurons. Herein, we presen ...

Public Library of Science2011

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

Pierre Magistretti, Jean-Luc Martin, Igor Allaman

RATIONALE: The pharmacological actions of most antidepressants are ascribed to the modulation of serotonergic and/or noradrenergic transmission in the brain. During therapeutic treatment for major depression, fluoxetine, one of the most commonly prescribed ...

Springer Verlag2011

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Jeffrey Alan Hubbell, Mikaël Martino, Federico Tortelli, Mayumi Mochizuki Martino

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011

Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning

Matthias Lütolf, Adrian Ranga, Martin Ehrbar

Engineered artificial microenvironments hold enormous potential as models to study developmental, physiological, pathological, and regenerative processes under highly defined conditions. Such platforms aim at bridging the gap between traditional in vitro 2 ...

2011

Engineering of Signaling Microenvironments with Fibronectin Domains to Enhance Tissue Regeneration

Mikaël Martino

Conducting tissue healing and regeneration through biomaterials and morphogens is still an unrealized goal. Understand the multiple roles of the extracellular matrix (ECM) is indeed essential for the design of successful regenerative medicine strategies. D ...

EPFL2011

An extracellular matrix protein microarray to study endothelial to mesenchymal transformation in mitral valve endothelial cells

Blaise Calpe

In the developing heart, a subset of endothelial cells (ECs) undergo a process of endothelial to mesenchymal transformation (EMT) that leads to the remodeling of the cardiac cushions and the formation of the cardiac valves. Understanding how microenvironme ...

2011

Cross-Lingual Speaker Discrimination Using Natural and Synthetic Speech

Hui Liang

This paper describes speaker discrimination experiments in which native English listeners were presented with natural speech stimuli in English and Mandarin, synthetic speech stimuli in English and Mandarin, or natural Mandarin speech and synthetic English ...

2011

Cross-Lingual Speaker Discrimination Using Natural and Synthetic Speech

Hui Liang

Idiap2011

Neurite guidance through 3D hydrogel layers in a microfluidic environment

Philippe Renaud, Robert Meissner, Anja Kunze

Neuronal cell culture models in vitro are often restricted to 2D surfaces. Engineering the complexity of the neuronal microenvironment in microfluidic systems can help to generate more tissue like cultures. We have developed a new neuronal cell culturing s ...

2010

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

Jeffrey Alan Hubbell, Mikaël Martino

It has recently been shown that some growth factors (GFs) have strong interactions with nonproteoglycan extracellular matrix proteins. Relevant here, the 12th-14th type three repeats of fibronectin (FN III12-14) have been shown to bind insulin-like growth ...

Federation of American Society of Experimental Biology2010

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