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Maximum life span

Science de la nature
Biologie
Biologie cellulaire
Vieillissement

Publications associées (29)

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Human mortality at extreme age

Anthony Christopher Davison, Léo Raymond-Belzile

We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyse the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, extreme-value modelling leads ...

ROYAL SOC2021

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

Joachim Lingner, Thomas Frédéric Lunardi, Marianna Feretzaki, Rita Valador Fernandes

Telomeres-repeated, noncoding nucleotide motifs and associated proteins that are found at the ends of eukaryotic chromosomes-mediate genome stability and determine cellular lifespan1. Telomeric-repeat-containing RNA (TERRA) is a class of long noncoding RNA ...

2020

NAD(+) homeostasis in health and disease

Johan Auwerx, Mario Romani, Elena Katsyuba, Dina Hofer

The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to ...

2020

Gamified Motor Training With Tangible Robots in Older Adults: A Feasibility Study and Comparison With the Young

Pierre Dillenbourg, Friedhelm Christoph Hummel, Wafa Monia Benkaouar Johal, Maximilian Jonas Wessel, Ayberk Özgür, Jennifer Kaitlyn Olsen, Arzu Güneysu Özgür

Background: An increasing lifespan and the resulting change in our expectations of later life stages are dependent on a good health state. This emphasizes the importance of the development of strategies to further strengthen healthy aging. One important as ...

2020

Life-history trade-offs and limitations associated with phenotypic adaptation under future ocean warming and elevated salinity

Emma Mary Gibbin, Félix Christen

Little is known about the life-history trade-offs and limitations, and the physiological mechanisms that are associated with phenotypic adaptation to future ocean conditions. To address this knowledge gap, we investigated the within-and trans-generation li ...

ROYAL SOC2019

Cross-species functional modules link proteostasis to human normal aging

Johan Auwerx, Hao Li, Vincenzo Sorrentino, Andrea Komljenovic

The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Kristina Schoonjans, Bernard Schneider, Graham Knott, Davide D'Amico, Vera Monica Lemos Da Silva, Mario Romani, Vincenzo Sorrentino, Adrienne Joëlle Laurence Mottis, Hao Li

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko

Commensal microbes colonize the gut epithelia of virtually all animals and provide several benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is associated with numerous pathologies and decreased lifespan. Peptidoglycan ...

2018

The double-edged toxins : how Spiroplasma Ribosome-Inactivating Proteins affect Drosophila melanogaster life history traits

Mario Gonzalo Garcia Arraez

Many insect species are associated with endosymbiotic bacteria which have the particularity of living within host tissues. Endosymbionts benefit from this stable and nutritious environment, while providing ecological advantages to their host, such as prote ...

EPFL2018

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Hüseyin Baris Atakan

We present a multiplexed and automated microfluidic platform for phenotyping of C. elegans during their full lifespan and at high-throughput. We used the fluorescent hsp-6::gfp strain of worms and performed experiments to observe the effect of four differe ...

2017

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Life-history trade-offs and limitations associated with phenotypic adaptation under future ocean warming and elevated salinity

Emma Mary Gibbin, Félix Christen

ROYAL SOC2019

Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko

2018

NAD(+) homeostasis in health and disease

Johan Auwerx, Mario Romani, Elena Katsyuba, Dina Hofer

2020

Gamified Motor Training With Tangible Robots in Older Adults: A Feasibility Study and Comparison With the Young

Pierre Dillenbourg, Friedhelm Christoph Hummel, Wafa Monia Benkaouar Johal, Maximilian Jonas Wessel, Ayberk Özgür, Jennifer Kaitlyn Olsen, Arzu Güneysu Özgür

2020

The double-edged toxins : how Spiroplasma Ribosome-Inactivating Proteins affect Drosophila melanogaster life history traits

Mario Gonzalo Garcia Arraez

EPFL2018