Concept

Maximum life span

Publications associées (55)

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Evan Graehl Williams, Norman Lionel Moullan, Hongbo Zhang, Eija Riitta Pirinen, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li

We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...

Elsevier2014

Mitonuclear protein imbalance as a conserved longevity mechanism

Johan Auwerx, Graham Knott, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

2013

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

Johannes Gräff

Caloric restriction (CR) is a dietary regimen known to promote lifespan by slowing down the occurrence of age-dependent diseases. The greatest risk factor for neurodegeneration in the brain is age, from which follows that CR might also attenuate the progre ...

Society for Neuroscience2013

Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

Istvan Bartha

Quantitative knowledge of the turnover of different leukocyte populations is a key to our understanding of immune function in health and disease. Much progress has been made thanks to the introduction of stable isotope labeling, the state-of-the-art techni ...

Amer Soc Hematology2013

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis

NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further red ...

Cell Press2013

Dynamic ornament: An investigation of responsive thermochromic surfaces in architecture

Jeffrey Huang, Mark Meagher, David Van der Maas, Christian Abegg

This paper describes the use of environmental sensor data as a basis for the design of architectural ornament that takes on a distinctive appearance in response to the atmospheric conditions where it is located. Among the goals of the project were the iden ...

2013

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused by an ...

Public Library Science2013

In-vivo condition monitoring of metallic implants by electrochemical techniques

Stefano Mischler, Eric Meurville

The invention relates to a replacement metallic prosthesis to be implanted which contains means monitor its condition during use in order to allow an early detection of failure or insufficient functionality, wherein said means comprise implanted sensors an ...

2013

The human CST complex is a terminator of telomerase activity

Joachim Lingner, Sophie Redon, Liuh-Yow Chen

The lengths of human telomeres, which protect chromosome ends from degradation and end fusions(1,2), are crucial determinants of cell lifespan(3). During embryogenesis and in cancer, the telomerase enzyme counteracts telomeric DNA shortening. As shown in c ...

Nature Publishing Group2012

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