Concept
Diazépam
Publications associées (18)
Divalent Cation Dependence Enhances Dopamine Aptamer Biosensing
Oligonucleotide receptors (aptamers), which change conformation upon target recognition, enable electronic biosensing under high ionic-strength conditions when coupled to field-effect transistors (FETs). Because highly negatively charged aptamer backbones ...
2021Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors
Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Fiona Hollis, Michael van der Kooij, Ioannis Zalachoras, Laura Lozano Montes, Sonia Abad Florensa
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...
Nature Publishing Group2018GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats
Maria del Carmen Sandi Perez, Michael van der Kooij, Ioannis Zalachoras
Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...
2018Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)
Stewart Cole, Anthony Vocat, Shi-Yan Caroline Foo, Andréanne Lupien, Jean-Yves Gillon
The efficacy of the standardized four-drug regimen (comprising isoniazid, rifampin, pyrazinamide, and ethambutol) for the treatment of tuberculosis (TB) is menaced by the emergence of multidrug-resistant (MDR) and extensively drugresistant (XDR) strains of ...
AMER SOC MICROBIOLOGY2018Valproic acid potentiates the anticancer activity of capecitabine <i>in vitro</i> and <i>in vivo</i> in breast cancer models via induction of thymidine phosphorylase expression
The prognosis of patients with metastatic breast cancer remains poor, and thus novel therapeutic approaches are needed. Capecitabine, which is commonly used for metastatic breast cancer in different settings, is an inactive prodrug that takes advantage of ...
2016The impact of anxiety and reward-seeking traits on social competition and the role of the mesolimbic dopaminergic system
Social hierarchies are established across a range of different taxa in the animal kingdom. Given that hierarchy inequalities are highly present in nowadays society and the health problems that low rank individuals suffer from this, it is surprising that no ...
EPFL2015Synthesis and Photophysical Properties of Ln(III)-DOTA-Bipy Complexes and Ln(III)-DOTA-Bipy-Ru-II Coordination Conjugates
Jean-Claude Bünzli, Svetlana Eliseeva
The synthesis and the systematic and comparative photo-physical study of a series of visible (Eu-III, Tb-III) and NIR-emitting (Nd-III, Yb-III) lanthanide complexes (Ln(2)L) and ruthenium lanthanide coordination conjugates (Ln(2)LRu) are reported. The Gd-I ...
Wiley-Blackwell2010