Concept

Gating (electrophysiology)

Publications associées (52)

The impact of selected water quality parameters on the inactivation of Bacillus subtilis spores by monochloramine and ozone

Selected water quality parameters-pH, dissolved organic carbon, turbidity (NTU), and temperature-were tested for their potential effects on ozone and monochloramine inactivation of Bacillus subtilis spores. In oxidant demand-free phosphate-buffer, temperat ...

2006

Structure and function of the nicotinic acetylcholine receptor

Jörg Grandl

The subject of this thesis is the study of the structure and function of the human muscle nicotinic acetylcholine receptor (nAChR), which is a typical member of the large class of ligand-gated ion channels. Appropriate techniques, like site-directed mutage ...

EPFL2005

Calcium dynamics and vasomotion in rat mesenteric arteries

Nikolaos Stergiopoulos, Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster, Mathieu Lamboley

Smooth muscle cell calcium dynamics and diameter were measured in intact pressurized rat mesenteric artery segments during vasoconstriction and vasomotion. Arteries showed a certain norepinephrine (NE) threshold (0.3-0.4 microM) for the onset of vasomotion ...

2004

Membrane trafficking in neurons regulated by new syntaxin 13-interacting proteins

Pascal Steiner

Recently, it has been shown that correct trafficking of neuronal plasma membrane receptors along the endosomal pathway is directly implicated in molecular mechanisms underlying synaptic plasticity and is fundamental for proper neuronal communication. To un ...

EPFL2004

A biophysical model of atrial fibrillation and electrograms

Vincent Jacquemet

Atrial arrhythmias are the most frequent rhythm disorders in humans and often lead to severe complications such as heart failure and stroke. While different mapping techniques have provided significant information on the electrophysiological processes asso ...

EPFL2004

QM/MM Car-Parrinello molecular dynamics study of selectivity in a potassium channel

Ursula Röthlisberger, Denis Bucher, Paolo Carloni, Leonardo Guidoni

All biol. ion channels are selectively permeable to specific ions. This mechanism needs to be understood in terms of the interaction of the permeating ions with the surrounding water and protein mols. During the past several years, there have been enormous ...

2004

Native membranes on subwavelentgh holes for membrane receptors analysis

Jürgen Brugger, Benjamin André René Meyer

How membrane receptors transduce external signals across the membrane and activate intracellular processes is a key question for fundamental research and for therapeutic purposes. Reliable in situ investigations requiest to preserve the full biological act ...

2004

A quantitative analysis of L-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics

Pierre Magistretti, Pierre Marquet, Jean-Yves Chatton

The mode of Na+ entry and the dynamics of intracellular Na+ concentration ([Na+]i) changes consecutive to the application of the neurotransmitter glutamate were investigated in mouse cortical astrocytes in primary culture by video fluorescence microscopy. ...

2000

Novel benzo-15-crown-5 functionalized α-olefin/CO terpolymers for membrane applications

Harm-Anton Klok

The synthesis of a benzo-15-crown-5 functionalized α-olefin (4′-(undec-10-enylcarboxylate)benzo-15-crown-5, 5) and its terpolymerization with carbon monoxide and various α-olefins are described. A decline of the glass transition temperatures (Tg) of the co ...

1997

Store operated calcium entry

Carl Petersen

Many hormones, growth factors and neurotransmitters stimulate the production of inositol 1,4,5-trisphosphate evoking the release of calcium from intracellular stores. The depletion of these intracellular calcium stores subsequently activates a voltage-inde ...

1996

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