Publications associées à Noyau pédonculopontin

alpha-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)

Bernard Schneider, Liliane Glauser, Elpida Tsika, Darren Moore, Alessandra Musso, Guillaume Daniel, Aris Nikolaos Fiser

Mutations in the ATP13A2 (PARK9) gene cause early-onset, autosomal recessive Parkinson's disease (PD) and Kufor-Rakeb syndrome. ATP13A2 mRNA is spliced into three distinct isoforms encoding a P5-type ATPase involved in regulating heavy metal transport acro ...

Academic Press Inc Elsevier Science2015

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease

Hubert van den Bergh, Hilal Lashuel, Georges Wagnières, Blaise Lovisa, Abid Oueslati, John Perrin

Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including n ...

Public Library of Science2015

Automatic target validation based on neuroscientific literature mining for tractography

Jean-Cédric Chappelier, Sean Lewis Hill, Jocelyne Bloch, Bogdan Draganski, Renaud Luc Richardet, Xavier Vasques, David Slater

Target identification for tractography studies requires solid anatomical knowledge validated by an extensive literature review across species for each seed structure to be studied. Manual literature review to identify targets for a given seed region is ted ...

Frontiers Research Foundation2015

Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis

Hilal Lashuel, Nadine Aït Bouziad, Anass Chiki, Ritwik Burai

Parkinsons disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of intraneuronal inclusions consisting of aggregated and post-translationally modified a-synuclein (a-syn). Despite advances in the chemic ...

Amer Chemical Soc2015

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

Bernard Schneider, Graham Knott, Wojciech Janusz Bobela, Lu Zheng

Introduction: Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1 alpha, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as ...

Biomed Central Ltd2015

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Meritxell Bach Cuadra, Reto Meuli, Alessandro Daducci, Cristina Granziera, Daniel Andreas Schmitter, Alexis Roche, Guillaume Bonnier

Objectives: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). Methods: Forty-two MCI patients and 77 healthy co ...

Elsevier2015

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Grégoire Courtine, Laetitia Danielle Philippine Baud, Isabel Laura Vollenweider

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. alpha synuclein (alpha-syn) is a major constituent o ...

Biomed Central Ltd2015

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

Bernard Schneider, Pamela Solange Valdés Undurraga

Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although growing evidence indicates that endoplasmic reticulum (ER) stress is a hallmark of PD, its exact contribution to th ...

National Academy of Sciences2014

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Noyau pédonculopontin

Dopamine induces soluble alpha-synuclein oligomers and nigrostriatal degeneration

alpha-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease

Automatic target validation based on neuroscientific literature mining for tractography

Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

Cortical Control of Whisker Movement

Graph Chatbot

Chattez avec Graph Search

Automatic target validation based on neuroscientific literature mining for tractography

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

Cortical Control of Whisker Movement

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Dopamine induces soluble alpha-synuclein oligomers and nigrostriatal degeneration

Elucidating the Role of Site-Specific Nitration of alpha-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

alpha-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)