Publications associées à Breast development

An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

Marco Pisano, Valentina Triacca, Melody Swartz

The most common cancers, including breast and skin, disseminate initially through the lymphatic system, yet the mechanisms by which tumor cells home towards, enter and interact with the lymphatic endothelium remain poorly understood. Transmural and luminal ...

Royal Soc Chemistry2015

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Maryse Fiche, Tamara Tanos, Maria Gutierrez Najera

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

Cathrin Brisken

Abstract | Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxife ...

Nature Publishing Group2013

ID4 regulates mammary gland development by suppressing p38MAPK activity

Yiming Li, Cathrin Brisken, Marian Caikovski, Xiuwei Zhang, Jun Dong

The ID family of helix-loop-helix proteins regulates cell proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cel ...

2011

High hopes for RANKL: will the mouse model live up to its promise?

Cathrin Brisken, Tamara Tanos

The steroid hormones, estrogens and progesterone are key drivers of postnatal breast development and are linked to breast carcinogenesis. Experiments in the mouse mammary gland have revealed that they rely on paracrine factors to relegate their signal loca ...

BioMed Central2011

Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics

Cathrin Brisken, Lucia Jimenez Rojo

Amphiregulin (AREG), a ligand for epidermal growth factor receptor, is required for mammary gland ductal morphogenesis and mediates estrogen actions in vivo, emerging as an essential growth factor during mammary gland growth and differentiation. The COMMA- ...

Elsevier2010

Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression

Cathrin Brisken

Estrogen and progesterone are the defining hormones of normal female development, and both play critical roles in breast carcinogenesis. Cyclin D1 is a breast cancer oncogene whose amplification is linked to poor prognosis in estrogen and progesterone rece ...

American Society for Microbiology2010

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

Cathrin Brisken, Ayyakkannu Ayyanan, Marian Caikovski

The mouse mammary gland develops postnatally under the control of female reproductive hormones. Estrogens and progesterone trigger morphogenesis by poorly understood mechanisms acting on a subset of mammary epithelial cells (MECs) that express their cognat ...

National Academy of Sciences2010

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

Cathrin Brisken, Maryse Fiche

The breast epithelium has two major compartments, luminal and basal cells, that are established and maintained by poorly understood mechanisms. The p53 homolog, p63, is required for the formation of mammary buds, but its function in the breast after birth ...

Nature Publishing Group2010

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Breast development

An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

ID4 regulates mammary gland development by suppressing p38MAPK activity

High hopes for RANKL: will the mouse model live up to its promise?

Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics

Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

Role of canonical Wnt signaling in mammary gland development

Graph Chatbot

Chattez avec Graph Search

An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

High hopes for RANKL: will the mouse model live up to its promise?

Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics

Role of canonical Wnt signaling in mammary gland development

Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

ID4 regulates mammary gland development by suppressing p38MAPK activity

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates