Concept
Matériel péricentriolaire
Publications associées (19)
Dissecting centriole fate in C. elegans development
The presence of centrioles is critical for fundamental cell and developmental processes, including polarity, migration and division. Although centrioles are present in most proliferating cells, they are thought to vanish after cell cycle exit in some diffe ...
EPFL2022Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography
Henning Paul-Julius Stahlberg, Paul Guichard, Virginie Hamel
Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. While the crucial role of the proximal region in centriole biogenesis has been well documented, its native architecture ...
2020A helical inner scaffold provides a structural basis for centriole cohesion
Henning Paul-Julius Stahlberg, Davide Gambarotto, Paul Guichard, Virginie Hamel
The ninefold radial arrangement of microtubule triplets (MTTs) is the hallmark of the centriole, a conserved organelle crucial for the formation of centrosomes and cilia. Although strong cohesion between MTTs is critical to resist forces applied by ciliary ...
2020Isolation, cryotomography, and three-dimensional reconstruction of centrioles
Pierre Gönczy, Paul Guichard, Virginie Hamel, Aitana Neves da Silva
Centrioles and basal bodies (referred to hereafter as centrioles for simplicity) are microtubule-based cylindrical organelles that are typically ∼450-nm long and ∼250nm in diameter. The centriole is composed of three distinct regions: the distal part chara ...
Elsevier2015