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Publications associées (68)

Adaptation of short-term plasticity parameters via error-driven learning may explain the correlation between activity-dependent synaptic properties, connectivity motifs and target specificity

The anatomical connectivity among neurons has been experimentally found to be largely non-random across brain areas. This means that certain connectivity motifs occur at a higher frequency than would be expected by chance. Of particular interest, short-ter ...

Frontiers Research Foundation2015

Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex

Henry Markram, Yun Wang, Shruti Muralidhar

Layer 1 of the neocortex is sparsely populated with neurons and heavily innervated by fibers from lower layers and proximal and distal brain regions. Understanding the potential functions of this layer requires a comprehensive understanding of its cellular ...

Frontiers Research Foundation2014

Dynamics of self-sustained asynchronous-irregular activity in random networks of spiking neurons with strong synapses

Marc-Oliver Gewaltig

Random networks of integrate-and-fire neurons with strong current-based synapse scan, unlike previously believed, assume stable states of sustained asynchronous and irregular firing, even without external random background or pacemaker neurons. We analyze ...

Frontiers Research Foundation2014

Learning improvement after PI3K activation correlates with de novo formation of functional small spines

Maria del Carmen Sandi Perez

PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide ...

2014

Robo3-Driven Axon Midline Crossing Conditions Functional Maturation of a Large Commissural Synapse

Ralf Schneggenburger, Zsolt Norbert Babai

During the formation of neuronal circuits, axon pathfinding decisions specify the location of synapses on the correct brain side and in correct target areas. We investigated a possible link between axon midline crossing and the subsequent development of ou ...

Elsevier2013

BMP signaling specifies the development of a large and fast CNS synapse

Graham Knott, Ralf Schneggenburger, Enida Gjoni, Elin Kristina Kronander, Le Xiao

excitatory synapses with multiple active zones ensure reliable and fast information transfer at specific points in neuronal circuits. However, the mechanisms that determine synapse size in CNS circuits are largely unknown. Here we use the calyx of Held syn ...

Nature Publishing Group2013

Lithium rescues synaptic plasticity and memory in Down syndrome mice

Diego Ghezzi

Down syndrome (DS) patients exhibit abnormalities of hippocampal-dependent explicit memory, a feature that is replicated in relevant mouse models of the disease. Adult hippocampal neurogenesis, which is impaired in DS and other neuropsychiatric diseases, p ...

American Society for Clinical Investigation2013

VGLUT1 is localized in astrocytic processes in several brain regions

Mats Julius Stensrud

During the last years, the concept of gliotransmission has been established. Glutamate has been shown to be released from astrocytes by different mechanisms, e.g., in an exocytotic manner. The authors have previously shown that astrocytes in the dentate-mo ...

2012

Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability

Maria del Carmen Sandi Perez

The exact function of the adult brain neurogenesis remains elusive, although it has been suggested to play a role in learning and memory processes. In our studies, we employed cyclin D2 gene knockout (cD2 KO) mice showing impaired neurogenesis as well as d ...

2012

Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement

Maria del Carmen Sandi Perez, Erika Myrna Borcel Novoa, Lidia Alonso-Nanclares

Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from ...

2012

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