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Publications associées (68)

Modified Trans-synaptic Tracing Viruses Reveal Novel Connectivity in the Rat Olfactory Bulb

Olfaction and the olfactory pathway is a good system to study sensory processing in general, mainly because of the simplified organization of the cells constituting the olfactory bulb, the anatomical structure responsible for early odor encoding and proces ...

2008

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both munc13 and protein kinase C

Ralf Schneggenburger, Natalya Korogod

Diacylglycerol (DAG) and phorbol esters strongly potentiate transmitter release at synapses by activating protein kinase C (PKC) and members of the Munc13 family of presynaptic vesicle priming proteins. This PKC/Munc13 pathway has emerged as a crucial regu ...

Society for Neuroscience2008

Slow oscillations in neural networks with facilitating synapses

Henry Markram, Gilad Silberberg

The synchronous oscillatory activity characterizing many neurons in a network is often considered to be a mechanism for representing, binding, conveying, and organizing information. A number of models have been proposed to explain high-frequency oscillatio ...

Springer US2008

Tag-Trigger-Consolidation: A Model of Early and Late Long-Term-Potentiation and Depression

Wulfram Gerstner, Eleni Vasilaki, Claudia Clopath, Lorric Ziegler

Changes in synaptic efficacies need to be long-lasting in order to serve as a substrate for memory. Experimentally, synaptic plasticity exhibits phases covering the induction of long-term potentiation and depression (LTP/LTD) during the early phase of syna ...

Public Library of Science2008

TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity

Pierre Magistretti, Kim Do, Jean-René Cardinaux

A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term mem ...

2007

Spontaneous and evoked synaptic rewiring in the neonatal neocortex

Henry Markram, Jean-Vincent Le Bé

The local microcircuitry of the neocortex is structurally a tabula rasa, with the axon of each pyramidal neuron having numerous submicrometer appositions with the dendrites of all neighboring pyramidal neurons, but is functionally highly selective, with sy ...

2006

Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana

Chronic restraint stress is known to affect the morphology and synaptic organization of the hippocampus, predominantly within CA3 but also in CA1 and dentate gyrus. In this study, we provide the first evidence for specific ultrastructural alterations affec ...

2006

Triplets of Spikes in a Model of Spike Timing-Dependent Plasticity

Wulfram Gerstner, Jean-Pascal Théodor Pfister

Classical experiments on spike timing-dependent plasticity (STDP) use a protocol based on pairs of presynaptic and postsynaptic spikes repeated at a given frequency to induce synaptic potentiation or depression. Therefore, standard STDP models have express ...

2006

Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking

Pierre Magistretti, Luc Pellerin

MCT2 is the main neuronal monocarboxylate transporter needed by neurons if they are to use lactate as an additional energy substrate. Previous evidence suggested that some MCT2 could be located in postsynaptic elements of glutamatergic synapses. Using post ...

2005

Mammalian motor neurons corelease glutamate and acetylcholine at central synapses

Jesper Ryge

Motor neurons (MNs) are the principal neurons in the mammalian spinal cord whose activities cause muscles to contract. In addition to their peripheral axons, MNs have central collaterals that contact inhibitory Renshaw cells and other MNs. Since its origin ...

National Academy of Sciences2005

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