Concept

Endoréplication

Publications associées (14)

Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutS gamma complex

Crossover formation is essential for proper segregation of homologous chromosomes during meiosis. Here, we show that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) partners with cyclin-like protein COSA-1 to promote crossover formation by promoti ...

NATL ACAD SCIENCES2022

Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size

Suliana Manley, Anna Archetti, Lina Carlini, Charlotte Sophia Floderer, Thaïs Reichler

Protein concentration gradients pattern developing organisms and single cells. In Schizosaccharomyces pombe rod-shaped cells, Pom1 kinase forms gradients with maxima at cell poles. Pom1 controls the timing of mitotic entry by inhibiting Cdr2, which forms s ...

ELIFE SCIENCES PUBLICATIONS LTD2019

Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage

Gérald Joseph Paul Lossaint, Katarina Bacevic

Although cyclin-dependent kinase 2 (Cdk2) controls the G1/S transition and promotes DNA replication, it is dispensable for cell cycle progression due to redundancy with Cdk1. Yet Cdk2 also has non-redundant functions that can be revealed in certain genetic ...

Springer Nature2017

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Pierre Gönczy, Coralie Busso, Sachin Kotak

Accurate spindle positioning is essential for error-free cell division. The one-cell Caenorhabditis elegans embryo has proven instrumental for dissecting mechanisms governing spindle positioning. Despite important progress, how the cortical forces that act ...

2016

Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies

Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays multiple and essential roles during the cell division cycle. Its inhibition in cultured cells leads to severe mitotic aberrancies and cell death. Whereas previous reports suggested that Plk1 ...

Wiley-Blackwell2016

Continuum theory of gene expression waves during vertebrate segmentation

Andrew Charles Oates, Daniele Soroldoni

The segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here we pr ...

2015

Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe

Viesturs Simanis, Andrea Krapp, Elena Cano

Cytokinesis in Schizosaccharomyces pombe begins at mitotic entry, when the site of division is defined by formation of the contractile acto-myosin ring (CAR) at the cell cortex. Contraction of the CAR and formation of the division septum are triggered at t ...

2008

Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling

Peter Martin Beard, Michail Fragkos

Adeno-associated virus (AAV) DNA, by mimicking a stalled replication fork, provokes a DNA damage response that can arrest cells in the G2/M phase of the cell-cycle. This response depends strictly on DNA damage signaling kinases ATR and Chk1. Here, we used ...

2007

Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition

The transcription factor Myc plays a central role in the control of cellular proliferation. Myc expression is induced by growth factors in a pathway mediated by cellular Src (c-Src), but it is not clear whether Myc induction or activity is required for mal ...

2006

Cell cycle control in Plasmodium falciparum: a genomics perspective

The molecular mechanisms regulating cell proliferation and development in malaria parasites are still largely unknown. Phenomenological observations, pertaining to the organisation of the cell cycle during schizogony or to the signal transduction pathways ...

Caister Academic Press2004

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