Concept
Immunosuppresseur
Publications associées (64)
A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies
Didier Trono, Norman Lionel Moullan
Introduction: COVID-19 remains a significant risk for the immunocompromised given their lower responsiveness to vaccination or infection. Therefore, passive immunity through long-acting monoclonal antibodies (mAbs) offers a needed approach for pre-exposure ...
2024Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma
Background Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The tumor microenvironment content, particularly the presence of macrophages, was described as crucial for the development of the disease. This wo ...
2020Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2
Nadine Fournier, Mauro Delorenzi, Sina Nassiri, Borja Prat Luri, Laureline Wetterwald
Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and pathological angiogene ...
CELL PRESS2019Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles
Francesco Stellacci, Ye Yang, Ahmet Bekdemir
We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads ...
2019Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity
Depletion of immunosuppressive tumor-associated macrophages (TAMs) or reprogramming toward a proinflammatory activation state represent different strategies to therapeutically target this abundant myeloid population. In this study, we report that inhibitio ...
2018