Concept

Leucocyte

Publications associées (433)

Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen

Outside-in integrin signaling regulates cell fate decisions in a variety of cell types, including hematopoietic stem cells (HSCs). Our earlier published studies showed that interruption of periostin (POSTN) and integrin-av (ITGAV) interaction induces faste ...

AMER ASSOC IMMUNOLOGISTS2021

Tumor-Promoting Ly-6G(+) SiglecF(high) Cells Are Mature and Long-Lived Neutrophils

Etienne Meylan

Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some of these cells' ...

2020

Cell type prioritization in single-cell data

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Claudia Kathe, Matthieu Pierre Gautier, Michael Alexander Skinnider, Thomas Haynes Hutson, Marco Milano

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. We present Augur, a method to prioritize the cell types most responsive to biological perturbations in single-cell data. Augur employs a machine-l ...

NATURE PUBLISHING GROUP2020

Tweaking DNA of myeloid cells curbs cancer spread

Michele De Palma, Ali Ghasemi

Blood cells called myeloid cells can facilitate metastasis - the spread of a tumour to distant organs. Taming these cells with drugs that alter the chemical structure of their DNA limits metastasis in mice. ...

NATURE PUBLISHING GROUP2020

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Jan Paul Dudzic, Elodie Julie Virginie Ramond, Bianca Marie Petrignani

In animals, growth is regulated by the complex interplay between paracrine and endocrine signals. When food is scarce, tissues compete for nutrients, leading to critical resource allocation and prioritization. Little is known about how the immune system ma ...

WILEY2020

Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis

Johan Auwerx, Antoine Jalil

Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a pivotal role in cell homeostasis, but its contribution to macrophage functions and host defense remains to be delineated. Here, we showed that lipopolysaccharide (LPS) ...

AMER SOC CLINICAL INVESTIGATION INC2020

The emerging roles of eosinophils in mucosal homeostasis

Nicola Harris, Kathleen Shah

Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. N ...

NATURE PUBLISHING GROUP2020

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond

Drosophila melanogaster's blood cells (hemocytes) play essential roles in wound healing and are involved in clearing microbial infections. Here, we report the transcriptional changes of larval plasmatocytes after clean injury or infection with the Gram-neg ...

PUBLIC LIBRARY SCIENCE2020

Durable and controlled depletion of neutrophils in mice

Etienne Meylan, Julien Robert Rémi Faget, Gael Luis Boivin, Caroline Anne-Lyse Contat, Jessica Christine Vazquez, Justine Pascual, Pierre-Benoit Bernard Ancey, Aspasia Gkasti

Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective ...

2020

The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration

Giuliana Rossi

Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory phenotype to sustain myogeni ...

2020

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search