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Worldwide increasing resistance of Plasmodium falciparum to common anti-malaria agents calls for the urgent identification of new drugs. Glycogen synthase kinase-3 (GSK-3) represents a potential screening target for the identification of such new compounds ...
This contribution describes the synthesis of polyphenylene dendrimers that are functionalized with up to 16 lysine residues or substituted with short peptide sequences composed of 5 lysine or glutamic acid repeats and a C- or N-terminal cysteine residue. P ...
Caspase-3 (I) is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. I is active as a dimer with 2 symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity lo ...
The influence of the surface morphology of semicrystalline polyamide 12 PA12! on the adhesion of thin silicon oxide coatings is analyzed by means of uniaxial fragmentation tests and scanning local-acceleration microscopy SLAM!. Two types of PA12 substrates ...
Gamma-secretase is a member of an unusual class of proteases with intramembrane catalytic sites. This enzyme cleaves many type I membrane proteins, including the amyloid beta-protein (Abeta) precursor (APP) and the Notch receptor. Biochemical and genetic s ...
Caspases are fundamental targets for pharmaceutical interventions in a variety of diseases involving disregulated apoptosis. Here, we present a quantum mechanics/mol. mechanics Car-Parrinello study of key steps of the enzymic reaction for a representative ...
The water-soluble complexes [{RuCl2(mTPPMS)(2)}(2)], [RuCl2(PTA)(4)], [RhCl(mTPPMS)(3)], [RhCl(mTPPTS)(3)], and [RhCl(PTA)(3)] (mTPPMS=sodium salt of meta-sulfonatophenyl-diphenylphosphine, mTPPTS=sodium salt oftris(meta-sulfonatophenyl) phosphine, and PTA ...
The electrochem. properties of IrO2 and RuO2 nanoparticles, deposited on synthetic B-doped diamond (BDD) surfaces, are discussed. After a description of the prepn. procedure and the morphol. characterization of BDD/IrO2 and BDD/RuO2 samples, the dispersion ...
A review is given on the so-called electrochem. promotion (EP) denoting an elec. controlled modification of the activity and/or selectivity of a heterogeneous catalyst. Efficient EP in dispersed catalyst systems can be achieved using porous solid-electroly ...
As a consequence of inherently weak interactions between the chloride anion and the 1-butyl-3-methylimidazolium cation (ca. 15 kJ/mol), chloride dissociation from a transition-metal complex can be thermodynamically disfavored in ionic liquids. Therefore, w ...
