Concept

Théorie du réseau idiotypique de Jerne

Publications associées (19)

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

CAR-T cell therapy has shown remarkable success in treating hematopoietic malignancies, but its efficacy in solid tumors is limited by T cell dysfunction, including exhaustion and senescence. In this study, we designed metabolically armored CAR-T cells to ...

EPFL2023

Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses

Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ phy ...

2021

Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation

Berna Ayse Özkale Edelmann, Christina Myra Tringides

Mesenchymal stem cell (MSC) therapies demonstrate particular promise in ameliorating diseases of immune dysregulation but are hampered by short in vivo cell persistence and inconsistencies in phenotype. Here, we demonstrate that biomaterial encapsulation i ...

NATL ACAD SCIENCES2019

Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch

The variability in transcription factor concentration among cells is an important developmental determinant, yet how variability is controlled remains poorly understood. Studies of variability have focused predominantly on monitoring mRNA production noise. ...

The Company of Biologists2019

miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation

Michele De Palma, Mario Leonardo Squadrito

MiR-511-3p is embedded in intron 5 of the CD206/MRC1 gene Mrc1, expressed by macrophage and dendritic cell populations. CD206 and miR-511-3p expression are co-regulated, and their contribution to intestinal inflammation is unclear. We investigated their ro ...

Nature Publishing Group2016

Determinants of HIV-1 broadly neutralizing antibody induction

Jacques Fellay, Christian Axel Wandall Thorball

Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet basic aspects of their induction remain poorly understood. Here we report on viral, host and disease factors that steer bnAb evolution using the results of a systema ...

Nature Publishing Group2016

The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

Bruno Lemaitre, Fanny Schüpfer

The innate immune system needs to distinguish between harmful and innocuous stimuli to adapt its activation to the level of threat. How Drosophila mounts differential immune responses to dead and live Gram-negative bacteria using the single peptidoglycan r ...

Nature Publishing Group2016

Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus

Gerardo Turcatti, Marc Chambon, Julien Bortoli Chapalay

Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation- ...

Nature Publishing Group2016

Modes of antigen presentation by lymph node stromal cells and their immunological implications

Sachiko Hirosue

Antigen presentation is no longer the exclusive domain of cells of hematopoietic origin. Recent works have demonstrated that lymph node stromal cell (LNSC) populations, such as fibroblastic reticular cells, lymphatic and blood endothelial cells, not only p ...

Frontiers Media Sa2015

Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

Bruno Lemaitre, Anna Dostalova

Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus ...

American Society for Microbiology2015

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