Concept
Granulocyte neutrophile
Publications associées (32)
Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth
Freddy Radtke, Nadine Fournier, Etienne Meylan, Justine Pascual, Amber Dawn Bowler, Anita Bodac, Vincent Roh
Elevated peripheral blood and tumor-infiltrating neutrophils are often associated with a poor patient prognosis. However, therapeutic strategies to target these cells are difficult to implement due to the life-threatening risk of neutropenia. In a genetica ...
Springernature2024Targeting the aging of tumor-associated neutrophils in lung cancer
Neutrophils are leukocytes that play a key role in innate immunity. Their mode of action in case of infection is well described, but their impact in different chronic diseases, such as cancer, remains unclear. Nevertheless, recent publications describe neu ...
EPFL2024Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme
Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...
Frontiers Media Sa2024Hyperthermic intrathoracic chemotherapy to control malignant pleural mesothelioma
OBJECTIVE: Malignant pleural mesothelioma (MPM) is a rare disease that has a poor response to conventional therapy. Hyperthermic intrathoracic chemotherapy (HITOC), a treatment combining fever-range hyperthermia with intrapleural cisplatin chemotherapy, ha ...
EPFL2023CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity
Daniele Tavernari, Albert Santamaria Martinez, Giovanni Ciriello
Tissues are organized in cellular niches, the composition and interactions of which can be investigated using spatial omics technologies. However, systematic analyses of tissue composition are challenged by the scale and diversity of the data. Here we pres ...
Berlin2023Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea
Alessio Mylonas, Yichen Wang, Jiaqi Chen
Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cleaves c ...
AMER SOC CLINICAL INVESTIGATION INC2023Using Machine Learning to Predict Mortality for COVID-19 Patients on Day 0 in the ICU
Nahal Mansouri, Sahand Jamal Rahi
Rationale: Given the expanding number of COVID-19 cases and the potential for new waves of infection, there is an urgent need for early prediction of the severity of the disease in intensive care unit (ICU) patients to optimize treatment strategies.Objecti ...
FRONTIERS MEDIA SA2022The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Andrea Ablasser, Muhammet Fatih Gülen, Théo Nass, Martin Schaller, Vivek Vijay Thacker, Kunal Sharma
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications1,2. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs 3–5). Although rapid induction of type I ...
2022Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies
The bacterium Streptococcus pyogenes is a common cause of both mild and severe human diseases resulting in substantial morbidity and mortality each year. No vaccines are available, and our understanding of the antibody response to this human pathogen is st ...
AMER SOC MICROBIOLOGY2022A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo
Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading microbes. These short immune effectors are conserved in plants, animals, and fungi. Early work showed that AMPs killed bacteria in generalist fashions in vitro: i.e. AMPs that ...
EPFL2022