Concept

Knee pain

Publications associées (86)

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...

EPFL2016

Influence of Spinal Cord Integrity on Gait Control in Human Spinal Cord Injury

Grégoire Courtine

Background. Clinical trials in spinal cord injury (SCI) primarily rely on simplified outcome metrics (ie, speed, distance) to obtain a global surrogate for the complex alterations of gait control. However, these assessments lack sufficient sensitivity to i ...

Sage Publications Inc2016

A patient-specific numerical musculoskeletal knee model

Adeliya Latypova

Total Knee Arthroplasty (TKA) is a well-accepted surgical treatment of severe cases of osteoarthritis. Surgery is associated with improved pain level, knee function and health-related quality of life. Despite advances in surgical techniques and implant des ...

EPFL2015

Impact of synovial fluid flow on temperature regulation in knee cartilage

Dominique Pioletti, Philippe Abdel Sayed, Valérie Hélène Emilie Malfroy Camine, Mohamadreza Nassajian Moghadam

Several studies have reported an increase of temperature in cartilage submitted to cyclic sinusoidal loading. The temperature increase is in part due to the viscous behavior of this tissue, which partially dissipates the input mechanical energy into heat. ...

Elsevier2015

The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis

Heinrich Hofmann, Lionel André Maurizi

Background Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize ...

Public Library of Science2015

Self-heating hydrogel for mechanically-controlled drug release

Mohamadreza Nassajian Moghadam

Due to our active lifestyle, knee cartilage is at risk for focal defects. Unfortunately, the native healing properties of the articular cartilage are very limited. New strategies to treat cartilage defects are then developed such as the local delivery of g ...

EPFL2015

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Dominique Pioletti, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in ...

Elsevier2014

Numerical model of Total Knee Replacement replicating chair rising

Tshahé Auria Anongba Varela

Although the procedure of total knee replacement (TKR) has been improved for the last decades, patients may still face postoperative complications. Specially, causes of complications related to patellar resurfacing, such as osteonecrosis, patellar bone fra ...

2014

Design and integration of an instrumented knee prosthesis

Matteo Simoncini

Total knee arthroplasty is nowadays one of the most important orthopedic surgery. It consists of a procedure in which parts of the knee are replaced by a prosthesis. The largest indication for total knee arthroplasty is osteoarthritis, a knee disease that ...

EPFL2014

Smart instrumentation for determination of ligament stiffness and ligament balance in total knee arthroplasty

Kamiar Aminian, Philippe Renaud, Arnaud Bertsch, Brigitte Jolles-Haeberli, Arash Arami, Willyan Hasenkamp Carreira

Ligament balance is an important and subjective task performed during total knee arthroplasty (TKA) procedure. For this reason, it is desirable to develop instruments to quantitatively assess the soft-tissue balance since excessive imbalance can accelerate ...

Elsevier Sci Ltd2014

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