Concept

Métastase cérébrale

Publications associées (95)

Trimetal-arene clusters with anticancer activity

The invention relates to new medicaments, pharmaceutical compns., and methods of treatment of cancer. The invention discloses trimetallic clusters for use as a medicament, in particular in the treatment of cancer including metastasis. Preferably, the com ...

2009

Trimetal-arene clusters with anticancer activity

Paul Joseph Dyson, Wee Han Ang

The invention relates to new medicaments, pharmaceutical compns. and methods of treatment of cancer. The invention discloses trimetallic clusters for use as a medicament, in particular in the treatment of cancer including metastasis. Preferably, the compds ...

2009

The interplay between the VEGF-C/VEGFR-3 axis and CCL21/CCR7 axis in tumor cell invasion

Amine Issa

There are two main routes for tumor spread and metastasis, the blood vasculature and the lymphatic system. A wide range of human carcinomas, including lung, colon and breast cancer, spread to distant sites via the lymphatic system. Preclinical and clinical ...

EPFL2009

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

Douglas Hanahan, Jun Lu, Hao Zhang

While altered expression of microRNAs (miRs) in tumors has been well documented, it remains unclear how the miR transcriptome intersects neoplastic progression. By profiling the miR transcriptome we identified miR expression signatures associated with step ...

Cold Spring Harbor Laboratory Press2009

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI

Giulio Gambarota

To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response to these therapies. In brain tumours, one such parameter is vascular leakage, which is a response ...

Nature Publishing Group2008

Reduction of brain metastases in plasminogen activator inhibitor-1 deficient mice with transgenic ocular tumors

Friedrich Beermann

Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear. We studied the impact of PAI-1 deficiency in a transgenic mouse model of ocular tumors originat ...

Oxford University Press2008

Modulation of the metastatic progression of breast cancer with an organometallic ruthenium compound

Paul Joseph Dyson, Gianni Sava

The modulation of the metastatic progression of breast cancer has been evaluated in vitro and in vivo with RAPTA-T, [Ru(η6-toluene)Cl2(PTA)], an organometallic ruthenium compd. In vitro RAPTA-T inhibits some steps of the metastatic process such as the deta ...

2008

Tissue engineering complex and mechanically active microenvironments for studies in asthma and cancer

Alice Anna Tomei

The goals of tissue engineering include recapitulating specific tissue functions for regenerative medicine and developing in vitro models of human tissues to study human physiology and pathophysiology and for testing and screening drugs before expensive cl ...

EPFL2008

Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice

Florian Maria Wurm, Lucia Baldi Unser

Invariant NKT (iNKT) cells are potent activators of DCs, NK cells, and T cells, and their antitumor activity has been well demonstrated. A single injection of the high-affinity CD1d ligand α-galactosylceramide (αGalCer) leads to short-lived iNKT cell activ ...

2008

Synthetic biomaterials as cell-responsive artificial extracellular matrices

Matthias Lütolf, Jeffrey Alan Hubbell

Cells in our tissues are exposed to complex arrays of biochemical and biophysical cues from their protein- and sugar-rich extracellular matrix (ECM). In concert with cell- intrinsic regulatory cascades, these temporally and spatially coordinated signals in ...

Imperial College Press2008

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