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Monitoring human metabolism is of crucial importance for personalized medicine. Many metabolic diseases can be treated by controlling various endogenous metabolites (e.g., glucose, lactate, cholesterol, etc.). Similarly, measuring the metabolism of exogeno ...
Diffusion-controlled hydrogel polymeric matrix devices have been among the most widely used drug delivery systems. How ever in homogeneous hydrogel the diffusional distance increase with time and hence, the release rate decreases. That results in high rele ...
In this study, we present a detailed characterization of the full α/β interface in the farnesyltransferase (FTase) enzyme, an important target in drug design efforts. This characterization is presented in terms of hot spots, warm spots, and null spots and ...
Robust and reliable measurements in electrochemical biosensing of molecules are crucial for personalized medicine. Electrochemical sensors based on cytochrome P450 can detect the large majority of drugs commonly used in pharmacological treatments. The same ...
G-protein coupled receptors (GPCRs) constitute the largest family of intercellular signaling molecules and are estimated to be the target of more than 50% of all modern drugs. As with most integral membrane proteins (IMPs), a major bottleneck in the struct ...
Les études menées par l'Office Fédéral de l'Environnement (OFEV) ont montré l'efficacité de l'ozone pour l'abattement des micropolluants, substances organiques qui sont difficilement dégradables et issues de diverses provenances. Suite à la mise en place d ...
We report on the electrochemical detection of anti-cancer drugs in human serum with sensitivity values in the range of 8–925 nA/µM. Multi-walled carbon nanotubes were functionalized with three different cytochrome P450 isoforms (CYP1A2, CYP2B6, and CYP3A4) ...
Drug-containing nanoparticles (NPs) with monodisperse, controlled particle sizes are highly desirable for drug delivery. Accumulating evidence suggests that NPs with sizes less than 50 nm demonstrate superior performance in vitro and in vivo. However, it i ...
Organic small molecules are of particular interest for medicinal chemistry since they comprise many biologically active compounds which are potential drugs. To understand this vast chemical space, we are enumerating all possible organic molecules to create ...
The cellular uptake and subcellular distribution including adduct formation with genomic DNA and uptake into mitochondria of two ruthenium(III)-based drugs in clinical trials, KP1019 and NAMI-A, and cisplatin, was investigated in cisplatin sensitive and re ...