Concept

Erythrocyte deformability

Publications associées (33)

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

Poor pharmacokinetic profiles are often the underlying reason for the failure of novel protein drugs to reach clinical translation. Current passive half-life improvement methods focus on increasing the apparent hydrodynamic radius of the drug. We sought to ...

American Chemical Society2010

Stored red blood cells: A changing universe waiting for its map(s)

Niels Erik Lion, David Crettaz, Olivier Rubin

The availability of stored red blood cells (RBCs) for transfusion remains an important aspect of the treatment of polytrauma, acute anemia or major bleedings. RBCs are prepared by blood banks from whole blood donations and stored in the cold in additive so ...

2010

SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases. The functions of the majority of protein kinases of Plasmodi ...

Birkhäuser-Verlag, Springer2010

Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopy

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Daniel Boss, Annick Hoffmann

Red blood cell (RBC) membrane fluctuations provide important insights into cell states. We present a spatial analysis of red blood cell membrane fluctuations by using digital holographic Microscopy (DHM). This interferometric and dye-free technique, posses ...

Elsevier2009

Proteins interacting with PfEMP1 in P. falciparum infected erythrocyte

Damien Jacot

During infection in humans, P. falciparum invades and refurbishes the red blood cells (RBCs) in order to persist and proliferate. Parasite survival depends on expression of a parasite encoded cytoadherence ligand at the surface of the infected RBC called P ...

2009

Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet

Red blood cell (RBC) parameters such as morphology, volume, refractive index, and hemoglobin content are of great importance for diagnostic purposes. Existing approaches require complicated calibration procedures and robust cell perturbation. As a result, ...

2008

Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance

Malaria symptoms occur during Plasmodium falciparum development into red blood cells. During this process, the parasites make substantial modifications to the host cell in order to facilitate nutrient uptake and aid in parasite metabolism. One significant ...

Public Library of Science2008

Digital holographic microscopy applied to life sciences

Christian Depeursinge, Tristan Colomb, Benjamin Rappaz, Pierre Marquet, Jonas Kühn, Florian Charrière

Digital holographic microscopy (DHM) is applied to life sciences applications and demonstrate its capability of real-time imaging and quantitative measurements of physiological parameters such as cell volume or mean cell hemoglobin concentration (MCHC) of ...

IEEE2007

Erythrocytes volume and refractive index measurement with a digital holographic microscope

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Jonas Kühn, Florian Charrière

Digital holographic microscopy (DHM) is a technique that allows obtaining, from a single recorded hologram, quantitative phase image of living cell with interferometric accuracy. Specifically the optical phase shift induced by the specimen on the transmitt ...

SPIE2007

Erythrocytes analysis with a Digital Holographic Microscope

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Jonas Kühn, Florian Charrière

Digital holographic microscopy (DHM) is a technique that allows obtaining, from a single recorded hologram, quantitative phase image of living cell with interferometric accuracy (Marquet et al., 2005). Specifically the optical phase shift induced by the sp ...

SPIE2007

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